Molecular encapsulation in supramolecular chemistry is the confinement of a guest molecule inside the cavity of a supramolecular host molecule (molecular capsule, molecular container or cage compounds). Examples of supramolecular host molecule include carcerands and endohedral fullerenes.
Reactivity of guests 
An important implication of encapsulating a molecule at this level is that the guest is prevented from contacting other molecules that it might otherwise react with. Thus the encapsulated molecule behaves very differently from the way it would when in solution. The guest molecule tends to be extremely unreactive and often has much different spectroscopic signatures. Compounds normally highly unstable in solution, such as arynes or cycloheptatetraene have been successfully isolated at room temperature when molecularly encapsulated.
One of the first examples of encapsulating a structure at the molecular level was demonstrated by Cram and coworkers  in which they were able to isolate highly unstable, antiaromatic cylobutadiene at room temperature by encapsulating it within a hemicarcerand. Isolation of cyclobutadiene allowed chemists to experimentally confirm one of the most fundamental predictions of the rules of aromaticity.
In another example  the cage consists of a gallium tetrahedral cluster compound stabilized by 6 bidentate catechol amide ligands residing at the tetrahedron edges. The guest is a 16 electron and thus very reactive ruthenium metallocene (an organometallic catalyst) with a cyclopentadienyl ligand (red) and a 1,3,7-octatriene ligand (blue). The total charge for this anion is 11 and the counterions are 5 tetramethyl ammonium cations and 6 potassium cations. The ruthenium compound decomposes in water within minutes but encapsulated it survives in water for weeks.
Large metalla-assemblies, known as metallaprisms, contain a conformationally flexible cavity that allows them to host a variety of guest molecules. These assemblies have shown promise as agents of drug delivery to cancer cells.
According to food chemist Udo Pollmer of the European Institute of Food and Nutrition Sciences in Munich, alcohol can be molecularly encapsulated in cyclodextrines, a sugar derivate. In this way, encapsuled in small capsules, the fluid can be handled as a powder. The cyclodextrines can absorb an estimated 60 percent of their own weight in alcohol. A US patent has been registered for the process as early as 1974.
See also 
- Alcohol powder: Alcopops from a bag, Westdeutsche Zeitung, 28 October 2004 (German)
- Preparation of an Alcohol Containing Powder, General Foods Corporation March 31, 1972
- ^ Cram, D. J.; Tanner, M. E.; Thomas, R., The taming of Cyclobutadiene Angewandte Chemie International Edition Volume 30, Issue 8, Pages 1024 - 1027 1991 Abstract
- ^ Stabilization of Reactive Organometallic Intermediates Inside a Self-Assembled Nanoscale Host Dorothea Fiedler, Robert G. Bergman, Kenneth N. Raymond Angewandte Chemie International Edition Volume 45, Issue 5, Pages 745 - 748 2006 Abstract
- Fraser Hof, Stephen L. Craig, Colin Nuckolls, Julius Rebek, Jr. Prof. (May 3, 2002). "Molecular Encapsulation". Angewandte Chemie International Edition. Volume 41 (9): 1488–1508. doi:10.1002/1521-3773(20020503)41:9<1488::AID-ANIE1488>3.0.CO;2-G. Retrieved April 19, 2013.