Mometasone furoate
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Mometasone furoate
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| Systematic (IUPAC) name | |
| (11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate | |
| Identifiers | |
| CAS number | 83919-23-7 as Furoate |
| ATC code | D07 D07, R01, R03 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C22H28Cl2O4 for Mometasone C27H30O6Cl2 as Furoate |
| Mol. mass | 427.361 g/mol (Mometasone) 521.4 g/mol (Furoate) |
| SMILES | & |
| Synonyms | (9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate |
| Pharmacokinetic data | |
| Bioavailability | Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone.[1] |
| Protein binding | 98% to 99% |
| Metabolism | hepatic |
| Half life | 5.8 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status | |
| Routes | topical, nasal |
Mometasone furoate (also referred to as mometasone) is a glucocorticoid steroid.[2]
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[edit] Uses, administration, and pharmacodynamics
It is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), and asthma[3] for patients unresponsive to less potent corticosteroids. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.
Schering-Plough markets the medication under the following brand names; Elocon (Elocom, Elomet) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions.
[edit] Availability
Generic Mometasone cream is available in the United States, manufactured by Taro Pharmaceuticals of Canada (distributed in the USA by such companies as Clay-Park Labs, Perrigo Company). Nasonex is not available as a generic in the USA (its patent won't run out until at least 2014), nor is Asmanex Twisthaler (its patent won't run out until at least 2012).
[edit] Cultural significance
Nasonex is known in the U.S. for a series of television ads featuring an animated bee which is voiced by the Spanish actor Antonio Banderas.[4][5]
[edit] References
- ^ Zia R Tayab, Tom C Fardon, Daniel K C Lee, Kay Haggart, Lesley C McFarlane, Brian J Lipworth, and Günther Hochhaus (November 2007). "Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate". 698–705. doi:. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17509041.
- ^ Tan RA, Corren J (December 2008). "Mometasone furoate in the management of asthma: a review". Ther Clin Risk Manag 4 (6): 1201–8. PMID 19337427.
- ^ Bousquet J (May 2009). "Mometasone furoate: an effective anti-inflammatory with a well-defined safety and tolerability profile in the treatment of asthma". Int. J. Clin. Pract. 63 (5): 806–19. doi:. PMID 19392928. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1368-5031&date=2009&volume=63&issue=5&spage=806.
- ^ "Antonio Banderas - Other Works". Internet Movie Database. http://www.imdb.com/name/nm0000104/otherworks.
- ^ ""Antonio Banderas Dons The Mask Once More"". Washington Post. http://www.washingtonpost.com/wp-dyn/content/article/2005/10/27/AR2005102700603.html.
[edit] External links
- Mometasone Furoate (Medline)
- Mometasone Furoate Inhalation (Medline)
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