Monatepil

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Monatepil
1 : 1 mixture (racemate)
Identifiers
CAS number 103379-03-9 YesY
PubChem 60810
ChemSpider 54798 N
KEGG D01171 N
Jmol-3D images Image 1
Properties
Molecular formula C28H30FN3OS
Molar mass 475.620703
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Monatepil is a calcium channel blocker and α1-adrenergic receptor antagonist used as an antihypertensive.[1]

Synthesis[edit]

Monatepil synthesis:[2]

References[edit]

  1. ^ Sugimoto T, Hosoki K, Karasawa T (July 1995). "Relative contribution of alpha 1-adrenoceptor blocking activity to the hypotensive effect of the novel calcium antagonist monatepil". Journal of Cardiovascular Pharmacology 26 (1): 55–60. doi:10.1097/00005344-199507000-00009. PMID 7564365. 
  2. ^ Kurokawa, M.; Sato, F.; Fujiwara, I.; Hatano, N.; Honda, Y.; Yoshida, T.; Naruto, S.; Mastumoto, J.; Uno, H. (1991). "A new class of calcium antagonists. 2. Synthesis and biological activity of 11-[4-[4-(4-fluorophenyl)-1-piperazinyl]butyryl]amino]-6,11-dihydrodibenzo[b,e]thiepin maleate and related compounds". Journal of Medicinal Chemistry 34 (3): 927. doi:10.1021/jm00107a009.  edit