Horan is best known for her appearance in the part of Amy McDougall (later Barone), Robert Barone's off-on again girlfriend, then wife, on the CBS-TV sitcom series Everybody Loves Raymond. Horan appeared in a total of 66 episodes of the series, making her first appearance in the episode titled "Who's Handsome?" (Season 1, episode #14). She currently lives in Los Angeles with her husband and their two children. Horan has recently guest starred on the Hot in Cleveland series (Season 2) playing an Amish woman.