Monoamine neurotransmitter

Norepinephrine is a monoamine neurotransmitter

A phylogenetic tree showing how a number of monoamine receptors are related to each other.

Monoamine neurotransmitters are neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by a two-carbon chain (-CH₂-CH₂-). All monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes.

Examples

• Histamine (His/H is Diamine)
• Catecholamines:
  • Dopamine (DA)
  • Noradrenaline (NA) (Norepinephrine, NE)
  • Adrenaline (Epinephrine)
• Tryptamines:
  • Serotonin (5-HT)
  • Melatonin
• Trace amines:
  • β-Phenylethylamine (PEA, β-PEA)
  • Tyramine
  • Tryptamine
  • Octopamine
  • 3-Iodothyronamine
  • Thyronamines, a new group of compounds derived from thyroid hormones

Specific transporter proteins called monoamine transporters that transport monoamines in or out of a cell exist. These are the dopamine transporter (DAT), serotonin transporter (SERT), and the norepinephrine transporter (NET) in the outer cell membrane and the vesicular monoamine transporter (VMAT1 and VMAT2) in the membrane of intracellular vesicles.

After release into the synaptic cleft, monoamine neurotransmitter action is ended by reuptake into the presynaptic terminal. There, they can be repackaged into synaptic vesicles or degraded by the enzyme monoamine oxidase (MAO), which is a target of monoamine oxidase inhibitors, a class of antidepressants.

See also

• Monoamine oxidase
• Monoamine transporter
• Neurotransmitter
• Monoamine Hypothesis

External links

• MeSH Biogenic+monoamines