Monobactams are β-lactam compounds wherein the β-lactam ring is alone and not fused to another ring (in contrast to most other β-lactams, which have at least two rings). They work only against Gram-negative bacteria.
The only commercially available monobactam antibiotic is aztreonam.
Adverse effects to monobactams can include skin rash and occasional abnormal liver functions.
They have no cross-hypersensitivity reactions with penicillin but like penicillins can trigger seizures in patients with history of seizures.
- Fuchs PC, Jones RN, Barry AL (March 1988). "In vitro antimicrobial activity of tigemonam, a new orally administered monobactam". Antimicrob. Agents Chemother. 32 (3): 346–9. PMC 172173. PMID 3259122.
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