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Monogenic may refer to:
- Analytic signal#The monogenic signal, in the theory of analytic signals
- Genetic disorder#Single gene disorder (or monogenic disorder, disease, inheritance, or trait), a single gene disorder is the result of a single mutated gene
- Maturity onset diabetes of the young (MODY; also known as monogenic diabetes), any of several hereditary forms of diabetes caused by mutations in an autosomal dominant gene disrupting insulin production
- Monogenic field, in mathematics, an algebraic number field K
- Monogenic function, a function in algebra over a field
- Monogenic semigroup, in mathematics, a semigroup generated by a set containing only a single element
- Monogenic system, in classical mechanics, a physical system
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