On May 20, 2013, parts of Moore and neighboring Newcastle and southern Oklahoma City, were affected by an intense multiple-vortex EF5 tornado. The tornado struck Briarwood Elementary School (South Oklahoma City), Plaza Towers Elementary School (Moore), and Highland East Junior High School . Briarwood and Plaza Towers sustained enough damage to be considered a total loss.Highland East's gym was for the most part destroyed. All out buildings were destroyed completely. Seven third graders inside Plaza Towers' 2nd-3rd grade annex lost their lives when the structure's walls collapsed.
On October 20, 2014 the district asked several employees and students who had been on a Carnival Cruise ship which had also been carrying a lab technician who may have come in contact with specimens from Ebola patient Thomas Eric Duncan three weeks earlier, not to return to school until the worker was cleared and there was no medical threat. The Lab technician tested negative and the employees and students were allowed to return to school.
The school district includes 31 schools, with preschool through 6th grade students attending elementary school, 7th and 8th grade students attending junior high school and 9th through 12th grade students attending high school.