Morosina Morosini-Grimani was the daughter of Andrea Morosini, a wealthy Venetian patrician. She was married in 1560 to Marino Grimani. With her husband's election as doge in 1595, her own coronation as official consort was conducted with enormous pomp and ceremony in 1597. No other dogaressa would be crowned after her until Elisabetta Querini in 1694, who would be the last dogaressa to be crowned. Morosina survived her husband and died at the age of seventy.
Dogaressa Morosina became the patron of the famous lace-making industry at Burano, and established a committee to promote and popularize the craft among the upper class women of Venice. She also restored the church of San Sebastiano from her own private fortune.