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Systematic (IUPAC) name
ethyl 1-(2-morpholin-4-ylethyl)-4-phenyl-piperidine-4-carboxylate
Clinical data
Legal status
CAS number 469-81-8 YesY
ATC code None
PubChem CID 61121
ChemSpider 55069 YesY
UNII 1854GKB41Y YesY
Chemical data
Formula C20H30N2O3 
Molecular mass 346.46 g/mol
 YesY (what is this?)  (verify)

Morpheridine (Morpholinoethylnorpethidine)[1] is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine). It is a strong analgesic with around 4 times the potency of pethidine,[2] and unlike pethidine, does not cause convulsions, although it produces the standard opioid side effects such as sedation and respiratory depression.[3]

Morpheridine is not currently used in medicine and is a Schedule I drug which is controlled under UN drug conventions.[4]


  1. ^ US 2795581, STERN EDWARD S; ANDERSON RONALD J, "Piperidine Compounds and Their Production", issued 06/11/1957, assigned to J.F. McFarlan & Co 
  2. ^ Holmes, J. M. (1958). "Morpholinoethylnorpethidine hydrochloride in obstetrics". The Journal of obstetrics and gynaecology of the British Empire 65 (1): 98–99. doi:10.1111/j.1471-0528.1958.tb06218.x. PMID 13514558.  edit
  3. ^ Green, A. F.; Ward, N. B. (1956). "Analgesic and other properties of morpholinoethylnorpethidine". British journal of pharmacology and chemotherapy 11 (1): 32–34. PMC 1509567. PMID 13304251.  edit
  4. ^ "Single convention on drugs 1961".