Morse Mill is an unincorporated community in Jefferson County, Missouri, United States. It is located about five miles northwest of Hillsboro. The community is named after John H. Morse, who settled here in 1847. Built in the early 1870s, the Morse homestead was a three-story frame house with a New Orleans-style balcony on the second floor. The house was used as a motel in the Roaring 20's, known as Morse Mill Hotel. At this hotel is where Bertha Gifford allegedly killed her first known victim. There is an abandoned mill dam on the Big River here.