Following his career in Orthodox Jewish institutions in the United States, Rabbi Meiselman emigrated to Jerusalem, where he opened Yeshivas Toras Moshe  Rabbi Meiselman, along with other close students of Rabbi Soloveitchik, subsequently cast Rabbi Soloveitchik in the role of a traditional haredi rosh yeshiva. Meiselman professes that Rabbi Soloveitchik's Zionism and secular studies were solely for the purpose of outreach and as a response to the assimilation of American Jews. This professed belief has attracted him the ire of many Modern Orthodox and Mizrachi thinkers.
After a disagreement about being mentioned in the acknowledgments in Rabbi Natan Slifkin's book, The Camel, The Hare, and The Hyrax, Meiselman made comments in a private conversation with several students at Yeshivas Toras Moshe criticizing both Rabbi Slifkin and his work, specifically his suggestion that the Sages of the Talmud were mistaken in certain scientific matters. Rabbi Slifkin sent a letter to Rabbi Meiselman rebutting the critiques of his work, calling the lectures "factually incorrect and extremely defamatory." Rabbi Slifkin subsequently posted audio of the conversation, that someone had recorded, on his website, with a note that he did receive a request to remove it from his website on the grounds that 'they were only intended for his yeshivah.'" Rabbi Meiselman subsequently wrote that those were private "off-the-cuff" conversations, and that they do not accurately represent his complete opinions, although Meiselman's recorded conversation begins with an explanation of why he "decided to discuss this with the entire student body."
Following the opinion of some haredi thinkers, Rabbi Meiselman has argued that the Holocaust was the result of Jewish cultural assimilation in Western Europe in the early twentieth century. He writes, "the turning away from the status of an 'am ha-nivhar, a chosen people, and the frightening rush toward assimilation were, according to the rules that govern Jewish destiny, the real causes for the Holocaust."