One of the most significant buildings remaining the early development of Mosher is the Hebrew Orphan Asylum. This 1876 Richardsonian Romanesque building became the West Baltimore General Hospital in 1923, then in 1945 became the Lutheran Hospital of Maryland. The hospital closed in 1989 and the building has been owned by Coppin State University since 2003.
The population neighborhood is predominantly African American and significantly low-income. According to 2000 Census data, 99% of Mosher households identify as African-American, .5% identifying as Asian, and .2% each identifying as white, American Indian and Alaska Native, or two or more races. The median household income was $24,667. Resident organizations in Mosher include the La Burt Improvement Association, Lafayette Community Association, Mosher Ridge Improvement Association, and Nehemiah House Community Association.