Mothers against decapentaplegic homolog 5

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SMAD family member 5
PDB 1khu EBI.jpg
PDB rendering based on 1khu.
Symbols SMAD5 ; DWFC; JV5-1; MADH5
External IDs OMIM603110 MGI1328787 HomoloGene4313 GeneCards: SMAD5 Gene
Species Human Mouse
Entrez 4090 17129
Ensembl ENSG00000113658 ENSMUSG00000021540
UniProt Q99717 P97454
RefSeq (mRNA) NM_001001419 NM_001164041
RefSeq (protein) NP_001001419 NP_001157513
Location (UCSC) Chr 5:
135.47 – 135.52 Mb
Chr 13:
56.7 – 56.74 Mb
PubMed search [1] [2]

Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.[1]

SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.


  1. ^ Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135.