Motor neuron disease
|Motor neuron disease|
|Classification and external resources|
A motor neuron disease (MND) is any of five neurological disorders that selectively affect motor neurons, the cells that control voluntary muscle activity including speaking, walking, swallowing, and general movement of the body. They are neurodegenerative in nature, and cause increasing disability and, eventually, death.
In the United States the term motor neuron disease is often used interchangeably with amyotrophic lateral sclerosis. The other four motor neuron diseases are: primary lateral sclerosis, progressive muscular atrophy, progressive bulbar palsy and pseudobulbar palsy. In the United Kingdom motor neurone disease is used to differentiate this disorder from the other motor neuron diseases though it is also known as amyotrophic lateral sclerosis. To avoid confusion, the annual scientific research conference dedicated to the study of MND is called the "International ALS/MND Symposium".
While MND refers to a specific subset of similar diseases, there are numerous other diseases of motor neurons that as a group are referred to as motor neuron disorders. Example include spinal muscular atrophy, spinobulbar muscular atrophy, Charcot–Marie–Tooth disease, Guillain–Barré syndrome, and many others.
|Type||UMN degeneration||LMN degeneration|
|Amyotrophic lateral sclerosis (ALS)||yes||yes|
|Primary lateral sclerosis (PLS)||yes||no|
|Progressive muscular atrophy (PMA)||no||yes|
|Progressive bulbar palsy (PBP)||no||yes – bulbar region|
|Pseudobulbar palsy||yes – bulbar region||no|
Even though diseases known as spinal muscular atrophies, including the most common spinal muscular atrophy (SMA), affect motor neurons and are classified as MND by the disease terminology classification system Medical Subject Headings (MeSH), they are not classified as such by the tenth International Statistical Classification of Diseases and Related Health Problems (ICD-10) published in 1992 and thus are not discussed in this article.
- Ellison, edited by Seth Love, David N. Louis, David W. (2008). Greenfield's neuropathology (8th ed. ed.). London: Hodder Arnold. p. 947. ISBN 9780340906811.
- "Motor Neuron Diseases Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS)". www.ninds.nih.gov. Retrieved 7 November 2010.
|Wikimedia Commons has media related to Motor neuron disease.|
- motor_neuron_diseases at NINDS
- MND Scotland, an independent charity registered in Scotland, and the only non-research charity working in Scotland for those with MND