On MTV, Pusha T explained the song's meaning: "It's the total disruption of radio. There's nothing on radio that will even be close to it. It just addresses Mr. Me Toos. Mr. Me Too is the person that sits there and examines your style and takes a piece of it. Also taken from the stage name Justin Meetoo. It addresses the competitive dude on the street who, when you get this or that they're like, 'Me too.'" He also said that the track also touches on some of what they went through with their label: "Briefly, 'cause we don't dwell."
The song also contains a reference to record label Jive, where the duo apologizes for the constant album delays ("These are the days of our lives / And I'm sorry to the fans but those crackers weren't playin' fair at Jive.") There was a W.V. boy working alongside them.
There is a remix which features Jay-Z and Nas, without Pharrell.