|Classification and external resources|
Mucicarmine staining is one stain used by pathologist for detection.
Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors.
This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells.
Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749.
Generally, there is a good prognosis for low-grade tumors, and a poor prognosis for high-grade tumors.
- Elsevier Article Locator
- Modern Pathology - Primary Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid Gland: A Report of Nine Cases
- Melnick M., Sedghizadeh P. P., Allen C. M., Jaskoll T. (10 November 2011). Experimental and Molecular Pathology 92 (1): 118–25. doi:10.1016/j.yexmp.2011.10.011. PMID 22101257 http://www.sciencedirect.com/science/article/pii/S0014480011001869
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- Isayeva T, Said-Al-Naief N, Ren Z, Li R, Gnepp D, Brandwein-Gensler M (2012) Salivary mucoepidermoid carcinoma: Demonstration of transcriptionally active human papillomavirus 16/18. Head Neck Pathol
- -489684982 at GPnotebook
- Overview at usc.edu
- Slide at jhu.edu
- mucoepidermoid carcinoma at humpath.com
- salivary mucoepidermoid carcinoma images at humpath.com