Multisystem developmental disorder (MSDD) is a term used by Stanley Greenspan to describe children under age 3 who exhibit signs of impaired communication as in autism, but with strong emotional attachments atypical of autism. It is described in the DC:0-3R manual as an optional diagnosis for children under two years of age.
The term multisystem developmental disorder has also been used to describe various developmental disorders. These include:
Alagille syndrome, an autosomal dominant disorder with a wide range of features and manifestations. Its five most significant features are chronic cholestasis, a condition where bile cannot flow from the liver to the duodenum, occurring in 95% of cases; heart abnormalities (over 90%); butterfly vertebrae; posterior embryotoxon and a distinctive face (prominent forehead, deep-set eyes, and a pointed chin).
Rubinstein-Taybi syndrome, a mental retardation syndrome characterized by broad thumbs, facial abnormalities, and big toes alongside mental retardation.
Williams syndrome, a neurodevelopmental disorder characterized by a unique profile of strengths and deficits; most with the condition have mild mental retardation but have grammatical and lexical abilities above what would be expected from their IQs. They are hypersocial and empathetic, but social isolation is commonly experienced.
^Oztop D, Uslu R (2007). "Behavioral, interactional and developmental symptomatology in toddlers of depressed mothers: a preliminary clinical study within the DC:0-3 framework". Turk. J. Pediatr.49 (2): 171–8. PMID17907517.
^Kamath, Binita M.; Stolle, Catherine; Bason, Lynn; Colliton, Raymond P.; Piccoli, David A.; Spinner, Nancy B.; Krantz, Ian D. (2002). "Craniosynostosis in Alagille syndrome". American Journal of Medical Genetics112 (2): 176–80. doi:10.1002/ajmg.10608. PMID12244552.
^Rio, Tony; Urbán, Zsolt; Csiszár, Katalin; Boyd, Charles D (2008). "A gene-dosage PCR method for the detection of elastin gene deletions in patients with Williams syndrome". Clinical Genetics54 (2): 129–35. doi:10.1111/j.1399-0004.1998.tb03715.x. PMID9761391.
^Scheiber, Dora; Fekete, Gyorgy; Urban, Zoltan; Tarjan, Ildiko; Balaton, Gergely; Kosa, Lajos; Nagy, Katalin; Vajo, Zoltan (2006). "Echocardiographic findings in patients with Williams-Beuren syndrome". Wiener klinische Wochenschrift118 (17–18): 538–42. doi:10.1007/s00508-006-0658-2. PMID17009066.
^Bellugi, Ursula; Wang, Paul P.; Jernigan, Terry L. (1994). "Williams syndrome: An unusual neuropsychological profile". In Broman, Sarah H.; Grafman, Jordan. Atypical cognitive deficits in developmental disorders: Implications for brain function. pp. 23–56. ISBN978-0-8058-1180-3.
Scheeringa, Michael S. (2001). "The differential diagnosis of impaired reciprocal social interaction in children: A review of disorders". Child Psychiatry and Human Development32 (1): 71–89. doi:10.1023/A:1017511714145. PMID11579660.