Murdock is an unincorporated community in Douglas County, Illinois, United States. Its elevation is 640 feet (195 m). Although Murdock is unincorporated, it has a post office, with the ZIP code of 61941.
Murdock was the site of a notable train derailment on September 2, 1983. A Baltimore and Ohio Railroad train derailed at 3:30 p.m., starting a fire. The fire heated tanks filled with liquefied petroleum gas, resulting in two large boiling liquid expanding vapor explosions. One of the tanker cars was blasted 3,630 feet (1,110 m) away from the derailment.