|Settled||1788 (as Franklin Township)|
|• Mayor||Robert J. Brooks|
|• Chief Administrator||James R Morrison|
|• Total||37 sq mi (100 km2)|
|Elevation||1,110 ft (338.3 m)|
|Time zone||Eastern (UTC-5)|
|• Summer (DST)||Eastern (UTC-4)|
According to the United States Census Bureau, the Municipality had a total area of 36.9 square miles (96 km2), of which, 36.9 square miles (96 km2) of it is land and 0.03% is water.
Among the neighborhoods within Murrysville are Murrysville Heights, Heather Highlands, Franklin Estates, Dunningtown, Newlonsburg, Ringertown, Sardis, and White Valley. Murrysville surrounds, but does not include, the Borough of Export, which is a separate municipal entity.
Murrysville is governed by a mayor (currently Robert Brooks) who is elected every two years and has executive/administrative powers, and a seven member council, whose members are elected every four years and have precise legislative powers.
As of the census of 2000, there were 18,872 people, 7,083 households, and 5,630 families residing in the borough. The population density was 511.0 people per square mile (197.3/km²). There were 7,396 housing units at an average density of 200.3 per square mile (77.3/km²). The racial makeup of the Municipality was 95.38% White, 0.61% African American, 0.05% Native American, 3.28% Asian, 0.01% Pacific Islander, 0.16% from other races, and 0.50% from two or more races. Hispanic or Latino of any race were 0.56% of the population.
There were 7,083 households out of which 34.5% had children under the age of 18 living with them, 71.8% were married couples living together, 5.5% had a female householder with no husband present, and 20.5% were non-families. 18.4% of all households were made up of individuals and 9.0% had someone living alone who was 65 years of age or older. The average household size was 2.63 and the average family size was 3.01.
In the Municipality the population was spread out with 24.9% under the age of 18, 4.9% from 18 to 24, 24.3% from 25 to 44, 30.3% from 45 to 64, and 15.6% who were 65 years of age or older. The median age was 43 years. For every 100 females there were 97.9 males. For every 100 females age 18 and over, there were 93.1 males.
The median income for a household in the Municipality was $64,071, and the median income for a family was $72,740. Males had a median income of $58,553 versus $32,567 for females. The per capita income for the borough was $32,017. About 2.2% of families and 2.8% of the population were below the poverty line, including 3.1% of those under age 18 and 3.9% of those age 65 or over.
Murrysville is within the Franklin Regional School District. The district operates five schools: three elementary (Sloan, Heritage, Newlonsburg), Franklin Regional Middle School, and Franklin Regional High School, with Dr. Gennaro Piraino  as the district's superintendent. Private schools include Mother of Sorrows Catholic School.
- Julie Benz (born 1972), actress
- Jeremiah Burrell (1815–1856), Western Pennsylvania lawyer and judge
- Walter Dollman, Jr (Born 1952), first elected Mayor of the Municipality of Murrysville in 1976
- Bobby Engram (born 1973), Seattle Seahawks wide receiver San Francisco 49ers Assistant offensive coordinator
- Eli Evankovich, PA House of Representatives, 54th District
- Tom Flynn (American football), defensive back for Green Bay Packers and New York Giants
- Ken Macha, Milwaukee Brewers manager
- Robert Moose, Pittsburgh Pirates, pitcher 1967-1976
- Manu Narayan (born 1973), actor
- Candace Otto, Miss Pennsylvania 2003
- Jessica Warman (born 1981), author
- Maddie Ziegler, Dance Moms reality star and actress 
The Haymaker Gas Well in Murrysville was the nation's first commercial natural gas well. For some time, it remained the largest commercial gas well in the world.
Since 1933, Murrysville has had a "tree sign" spelling out the word "Murrysville". The trees were landscaped to grow and form the letters by local Boy Scouts. The sign is situated on a large hill as one enters the Municipality from the Murrysville–Monroeville border, near U.S. Route 22. In 1947, the sign was featured in "Ripley's Believe It Or Not" as the world's largest arboreal sign. (It is no longer the world's largest, or even the largest in the country; "Luecke", near San Antonio, Texas, is much larger.) The "Y" in the Murrysville sign points to the Haymaker Gas Well.
- Population Estimates Boundary Changes, United States Census Bureau, 2007-07-01. Accessed 2008-11-06.
- "US Gazetteer files: 2010, 2000, and 1990". United States Census Bureau. 2011-02-12. Retrieved 2011-04-23.
- Murrysville Council
- "American FactFinder". United States Census Bureau. Retrieved 2008-01-31.
- "Land Patterns". Municipality of Murrysville. Retrieved 2007-10-26.[dead link]
- "About Murrysville". Municipality of Murrysville. Retrieved 2011-03-09.
- "Cook Honors College and IUP English Department Alumna, Jessica Warman, Publishes Her First Novel". PRWEB. April 7, 2010. Retrieved 2013-05-07.
- Cleary, Caitlin (2005-06-06). "Murrysville landmark is fading from view". Pittsburgh Post-Gazette.
- Municipality website
- Murrysville's official Community Magazine
- Murrysville Economic and Community Development Corporation
- The Murrysville Star
- Murrysville Business Directory
- News articles about the Murrysville tree sign and efforts to restore it: Pittsburgh Post-Gazette, February 16, 2006
- Penn-Franklin News, based in Murrysville