Amin and his brother were responsible for the five best selling publications in Egypt prior to the nationalization of the Egyptian press by Nasser in 1960.
In 1944 he took the post as editor of El-Ethnin, then, with his twin brother Ali Amin, launched the Saturday weekly paper Akhbar El Yom. Four years later the two brothers launched the daily Elakhbar. Within two years, the Akhbar el Yom group took over the daily newspaper Akher Saa. The group continued to publish magazines and weeklies over the years.
Mostafa Amin and his brother also encouraged the celebration of Mother's Day in Egypt, which takes place the 21st of March every year.