Hauduroy 1955, ATCC 12478
Mycobacterium kansasii is a bacterium in the Mycobacterium family. The genus includes species known to cause serious diseases in mammals, including tuberculosis and leprosy, but this species is generally not dangerous to healthy people.
- Smooth to rough colonies after 7 or more days of incubation.
- Colonies grown in dark are nonpigmented, when grown in light or when young colonies are exposed briefly to light, colonies become brilliant yellow (photochromogenic).
- If grown in a lighted incubator, most strains form dark red crystals of β-carotene on the surface and inside of colony.
- Growth on Middlebrook 7H10 agar at 37°C within 7 days or more.
- Resistant to pyrazinamide.
- Susceptible to ethambutol.
- Closely related to the non-pathogenic, also slowly growing, nonpigmented, M. gastri.
- Both species share an identical 16S rDNA but differentiation is possible by differences in the ITS and hsp65 sequences
- A commercial hybridisation assay (AccuProbe) to identify M. kansasii exists.
- Chronic human pulmonary disease resembling tuberculosis (involvement of the upper lobe).
- Extrapulmonary infections, (cervical lymphadenitis in children, cutaneous and soft tissues infections and musculoskeletal system involvement), are uncommon.
- Rarely causes disseminated disease except in patients with severely impaired cellular immunity (patients with organ transplants or AIDS).
- Patients with silicosis are at risk.
- Also appears in patients with hairy cell leukemia, but not in other lymphoproliferative disorders.
- Mycobacterium kansasii occasionally involves the skin in a sporotrichoid pattern.:341
- Normally considered not to be contagious from person to person.
- Natural sources of infections unclear. Tap water is believed to be the major reservoir associated with human disease.
- Biosafety level 2
- First and most frequently isolated from human pulmonary secretions and lesions.
Strain ATCC 12478 = CIP 104589 = DSM 44162 = JCM 6379 = NCTC 13024.
- Hauduroy,P. 1955. Derniers aspects du monde des mycobactéries. Masson et Cie, Paris, 1955.
- Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed. ed.). McGraw Hill. ISBN 0-8385-8529-9.
- Wintrobe, Maxwell Myer (2004). Wintrobe's clinical hematology. John G. Greer; John Foerster, John N. Lukens, George M Rodgers, Frixos Paraskevas (11 ed.). Hagerstown, MD: Lippincott Williams & Wilkins. p. 2467. ISBN 0-7817-3650-1.
- James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.