Myelin-associated glycoprotein

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Myelin associated glycoprotein
Identifiers
Symbols MAG ; GMA; S-MAG; SIGLEC-4A; SIGLEC4A
External IDs OMIM159460 HomoloGene1771 ChEMBL: 5807 GeneCards: MAG Gene
Orthologs
Species Human Mouse
Entrez 4099 17136
Ensembl ENSG00000105695 ENSMUSG00000036634
UniProt P20916 P20917
RefSeq (mRNA) NM_001199216 NM_010758
RefSeq (protein) NP_001186145 NP_034888
Location (UCSC) Chr 19:
35.78 – 35.8 Mb
Chr 7:
30.9 – 30.91 Mb
PubMed search [1] [2]
myelin associated glycoprotein
Identifiers
Symbol MAG
Alt. symbols GMA
Entrez 4099
HUGO 6783
OMIM 159460
RefSeq NM_080600
UniProt P20916
Other data
Locus Chr. 19 q13.1

Myelin-associated glycoprotein (MAG, Siglec-4) is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR.[1] MAG is believed to be involved in myelination during nerve regeneration.[2]

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References[edit]

  1. ^ Quarles RH (2007). "Myelin-associated glycoprotein (MAG): past, present and beyond". Journal of Neurochemistry 100 (6): 1431–48. doi:10.1111/j.1471-4159.2006.04319.x. PMID 17241126. 
  2. ^ Barton D, Arquint M, Roder J, Dunn R, Francke U (1987). "The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice". Genomics 1 (2): 107–12. doi:10.1016/0888-7543(87)90002-4. PMID 2447011.