Myelokathexis
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| Myelokathexis | |
|---|---|
| Classification and external resources | |
| ICD-9 | 288.0[1] |
| DiseasesDB | 32164 |
Myelokathexis is a congenital disorder of the white blood cells that causes severe, chronic leukopenia (a reduction of circulating white blood cells) and neutropenia (a reduction of neutrophil granulocytes).[2] The disorder is believed to be inherited in an autosomal dominant manner.[2][3] Myelokathexis refers to retention (kathexis) of neutrophils in the bone marrow (myelo).
[edit] Treatment
Myelokathexis is amongst the diseases treated with bone marrow transplantation and cord blood stem cells.[citation needed]
[edit] References
- ^ "ICD-9-CM Disease Index: M". http://www.dbmi.columbia.edu/hripcsak/icd9/2indexm.html. Retrieved 2008-02-17.
- ^ a b Aprikyan AA, Liles WC, Park JR, Jonas M, Chi EY, Dale DC (Jan 2000). "Myelokathexis, a congenital disorder of severe neutropenia characterized by accelerated apoptosis and defective expression of bcl-x in neutrophil precursors" (Free full text). Blood 95 (1): 320–327. PMID 10607719. http://www.bloodjournal.org/cgi/content/full/95/1/320.
- ^ Hord JD, W. J. (Sep-Oct 1997). "Clinical features of myelokathexis and treatment with hematopoietic cytokines: a case report of two patients and review of the literature". Journal of Pediatric Hematology/Oncology : official journal of the American Society of Pediatric Hematology/Oncology 19 (5): 443–448. PMID 9329467.
[edit] See also
- WHIM syndrome Warts, hypogammaglobulinemia, infections, and myelokathexis OMIM: 193670
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