MYF5

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Myogenic factor 5
Identifiers
Symbols MYF5 ; bHLHc2
External IDs OMIM159990 HomoloGene4085 GeneCards: MYF5 Gene
Orthologs
Species Human Mouse
Entrez 4617 17877
Ensembl ENSG00000111049 ENSMUSG00000000435
UniProt P13349 P24699
RefSeq (mRNA) NM_005593 NM_008656
RefSeq (protein) NP_005584 NP_032682
Location (UCSC) Chr 12:
81.11 – 81.11 Mb
Chr 10:
107.48 – 107.49 Mb
PubMed search [1] [2]

Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. [1] It is a protein with a key role in regulating muscle differentiation or myogenesis. Without Myf5 and MyoD, myogenic cells will fail to progress normally during the determination stage of myogenesis.

Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6).[2]

References[edit]

  1. ^ "Entrez Gene: Myogenic factor 5". Retrieved 2013-08-19. 
  2. ^ Sabourin LA, Rudnicki MA (2000). "The molecular regulation of myogenesis". Clin. Genet. 57 (1): 16–25. doi:10.1034/j.1399-0004.2000.570103.x. PMID 10733231. 

Further reading[edit]