Myiasis

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Myiasis
Classification and external resources
Miasis human.jpg
Cutaneous myiasis in the neck of a human
ICD-10 B87
ICD-9 134.0
DiseasesDB 29588
MeSH D009198

Myiasis (/ˈm.əsɨs/ or /mˈ.əsɨs/) is the parasitic infestation of the body of a live mammal by fly larvae (maggots) that grow inside the host while feeding on its tissue. Although flies are most commonly attracted to open wounds and urine- or feces-soaked fur, some species (including the most common myiatic flies, the botfly, blowfly and screwfly) can create an infestation even on unbroken skin and have even been known to use moist soil and non-myiatic flies (such as the common housefly) as vector agents for their parasitic larvae.

Colloquialisms for myiasis include flystrike and blowfly strike, and the victim or the tissue may be described as fly-blown. The name of the condition derives from ancient Greek μυῖα (myia), meaning "fly".

Because some animals (particularly domestic animals) cannot react as effectively as humans to the causes and effects of myiasis, such infestations present a severe and continuing problem for livestock industries worldwide, causing severe economic losses where they are not mitigated by human action.[1] Although typically a far greater issue for animals, myiasis is also a relatively frequent affliction of humans in rural tropical regions where myiatic flies thrive, and often may require medical attention to surgically remove the parasites.[2]

Myiasis varies widely in the forms it takes and its effects on the victims. Such variations depend largely on the fly species and where the larvae are located. Some flies lay eggs in open wounds, other larvae may invade unbroken skin or enter the body through the nose or ears, and still others may be swallowed if the eggs are deposited on the lips or on food.[2]

History of discovery[edit]

Myiasis in a cat's flesh

The Reverend Frederick William Hope coined the term myiasis in 1840 to refer to diseases resulting from dipterous larvae as opposed to those caused by other insect larvae (the term for this was scholechiasis). Hope described several cases of myiasis from Jamaica caused by unknown larvae, one of which resulted in death.[3]

Even though the term myiasis was first used in 1840, such conditions have been known since ancient times. Ambroise Paré, the chief surgeon to King Charles IX and King Henry III, observed that maggots often infested open wounds.[4]

Life cycle[edit]

The most common victim of myiasis worldwide is the domestic sheep, caused by the blowfly, especially where conditions are hot and wet. The life cycle in sheep is typical of the disease. The female flies lay their eggs on the sheep in damp, protected areas of the body that are soaked with urine and feces, mainly the sheep's breech (buttocks). It takes approximately eight hours to a day for the eggs to hatch, depending on the conditions. Once hatched, the larvae then lacerate the skin with their mouthparts, causing open sores. Once the skin has been breached, the larvae then tunnel through the sores into the host's subcutaneous tissue, causing deep and irritating lesions highly subject to infection. After about the second day, bacterial infection is likely and, if left untreated, causes toxemia or septicemia. This leads to anorexia and weakness and is generally fatal if untreated.

Blowfly strike accounts for over A$170 million a year in losses in the Australian sheep industry, the largest such losses in the world. Given the seriousness of the risk, Australian sheep farmers commonly perform preventive measures such as mulesing designed to remove the most common targets for the flies. The docking of lambs' tails (another frequently-soiled area which myiatic flies target) is also commonly practiced by sheep farmers worldwide. Maggots also commonly[citation needed] infest the vulvar area, causing the condition called vulvar myiasis.

Such problems are not peculiar to Australia and New Zealand; they occur worldwide, especially in countries where livestock, particularly sheep, are kept under hot, wet, conditions, including most of Africa and the Americas, ranging from the cold temperate regions in the north, to corresponding latitudes in the south. Myiasis is also not restricted to sheep; screwworm flies (Cochliomyia hominivorax in particular) regularly cause upwards of US$100 million in annual damages to domestic cows and goats,[5] though its impact has been heavily mitigated in recent years by the sterile insect technique.

Classifications[edit]

German entomologist Fritz Zumpt describes myiasis as "the infestation of live human and vertebrate animals with dipterous larvae, which at least for a period, feed on the host's dead or living tissue, liquid body substances, or ingested food". For modern purposes however, this is too vague. For example, feeding on dead or necrotic tissue is not generally a problem except when larvae such as those of flies in the family Piophilidae attack stored food such as cheese or preserved meats; such activity suggests saprophagy rather than parasitism; it even may be medically beneficial in maggot debridement therapy (MDT).

Currently myiasis commonly is classified according to aspects relevant to the case in question:

  1. The classical description of myiasis is according to the part of the host that is infected. This is the classification used by ICD-10. For example:[6]
    1. dermal
    2. sub-dermal
    3. cutaneous (B87.0)
      1. Creeping, where larvae burrow through or under the skin
      2. Furuncular, where a larva remains in one spot, causing a boil-like lesion
    4. nasopharyngeal nose, sinuses or pharynx. (B87.3)
    5. Ophthalmic or ocular in or about the eye (B87.2)
    6. Auricular in or about the ear
    7. gastric, rectal, or intestinal/enteric for the appropriate part of the digestive system(B87.8)
    8. urogenital (B87.8).
  2. Another aspect is the relationship between the host and the parasite and provides insight into the biology of the fly species causing the myiasis and its likely effect. Thus the myiasis is described as either:[6]
    1. Obligatory, where the parasite cannot complete its life cycle without its parasitic phase, which may be Specific, Semispecific, or Opportunistic.
    2. Facultative, incidental, or accidental, where it is not essential to the life cycle of the parasite; perhaps a normally free-living larva accidentally gained entrance to the host.[2]

Accidental myiasis commonly is enteric, resulting from swallowing eggs or larvae with one's food. The effect is called pseudomyiasis.[7] One traditional cause of pseudomyiasis was the eating of maggots of cheese flies in cheeses such as Stilton. Depending on the species present in the gut, pseudomyiasis may cause significant medical symptoms, but it is likely that most cases pass unnoticed.

Vectors in humans[edit]

There are three main fly families causing economically important myiasis in livestock and also, occasionally, in humans:

Other families occasionally involved are:

Specific myiasis[edit]

Caused by flies that need a host for larval development

Semispecific myiasis[edit]

Caused by flies that usually lay their eggs in decaying animal or vegetable matter, but that can develop in a host if open wounds or sores are present

Flesh flies, or sarcophagids, members of the family Sarcophagidae, can cause intestinal myiasis in humans if the females lay their eggs on meat or fruit.

Accidental myiasis[edit]

Also called pseudomyiasis. Caused by flies that have no preference or need to develop in a host but that will do so on rare occasions. Transmission occurs through accidental deposit of eggs on oral or genitourinary openings, or by swallowing eggs or larvae that are on food.

The adult flies are not parasitic, but when they lay their eggs in open wounds and these hatch into their larval stage (also known as maggots or grubs), the larvae feed on live and/or necrotic tissue, causing myiasis to develop. They may also be ingested or enter through other body apertures.

Clinical presentation in humans[edit]

How myiasis affects the human body depends on where the larvae are located. Larvae may infect dead, necrotic (prematurely dying) or living tissue in various sites: the skin, eyes, ears, stomach and intestinal tract, or in genitourinary sites.[8] They may invade open wounds and lesions or unbroken skin. Some enter the body through the nose or ears. Larvae or eggs can reach the stomach or intestines if they are swallowed with food and cause gastric or intestinal myiasis.[2]

Several different presentations of myiasis and their symptoms:[2]

Syndrome Symptoms
Cutaneous Myiasis Painful, slow-developing ulcers or furuncle- (boil-) like sores that can last for a prolonged period.
Nasal Myiasis Obstruction of nasal passages and severe irritation. In some cases facial edema and fever can develop. Death is not uncommon.
Aural Myiasis Crawling sensations and buzzing noises. Smelly discharge is sometimes present. If located in the middle ear, larvae may get to the brain.
Ophthalmomyiasis Fairly common, this causes severe irritation, edema, and pain.

Nosocomial Myiasis refers to myiasis in a hospital setting. It is quite frequent, as patients with open wounds or sores can be infested if flies are present. To prevent nosocomial myiasis, hospital rooms must be kept free of flies.

Human ophthalmomyiasis, both external and internal, has been caused by botfly larvae.[9]

Wound myiasis[edit]

Wound myiasis occurs when fly larvae infest open wounds. It has been a serious complication of war wounds in tropical areas, and is sometimes seen in neglected wounds in most parts of the world. Predisposing factors include poor socioeconomic conditions, extremes of age, mental retardation, psychiatric illness, alcoholism, diabetes, and vascular occlusive disease.[10][11][12][13][14]

Diagnostics[edit]

Myiasis is often misdiagnosed in the United States because it is extremely rare and its symptoms are not specific. Intestinal myiasis and urinary myiasis are especially difficult to diagnose.[2]

Clues that myiasis may be present include recent travel to an endemic area, one or more non-healing lesions on the skin, itchiness, movement under the skin or pain, discharge from a central punctum (tiny hole), or a small, white structure protruding from the lesion.[15] Serologic testing has also been used to diagnose the presence of botfly larvae in human ophthalmomyiasis.[9]

Control methods[edit]

The first control method is preventive and aims to eradicate the adult flies before they can cause any damage and is called vector control. The second control method is the treatment once the infestation is present, and concerns the infected animals (or humans).

Prevention[edit]

The principal control method of adult populations of myiasis inducing flies involves insecticide applications in the environment where the target livestock is kept. Organophosphorus or organochlorine compounds may be used, usually in a spraying formulation. One alternative prevention method is the SIT (Sterile Insect Technique) where a significant number of artificially reared sterilized (usually through irradiation) male flies are introduced. The male flies compete with wild bred males for females in order to copulate and thus cause females to lay batches of unfertilized eggs which can't develop into the larval stage.

One prevention method involves removing the environment most favourable to the flies, such as by docking (removal of the tail). Another example is the crutching of sheep, which involves the removal of wool from around the tail and between the rear legs, which is a favourable environment for the larvae. Another more permanent practice which is used in some countries is mulesing, where skin is removed from young animals to tighten remaining skin – leaving it less prone to fly attack.[16] Activists including PETA and several celebrities have been campaigning to have farmers cease mulesing.

To prevent myiasis in humans, there is a need for general improvement of sanitation, personal hygiene, and extermination of the flies by insecticides. Clothes should be washed thoroughly, preferably in hot water, dried away from flies, and ironed thoroughly. The heat of the iron kills the eggs of myiasis-causing flies.[15]

Treatment[edit]

This applies once an infestation is established. In many circles the first response to cutaneous myiasis once the breathing hole has formed, is to cover the air hole thickly with petroleum jelly. Lack of oxygen then forces the larva to the surface, where it can more easily be dealt with. In a clinical or veterinary setting there may not be time for such tentative approaches, and the treatment of choice might be more direct, with or without an incision. First the larva must be eliminated through pressure around the lesion and the use of forceps. Secondly the wound must be cleaned and disinfected. Further control is necessary to avoid further reinfestation.

Livestock may be treated prophylactically with slow release boluses containing ivermectin which can provide long term protection against the development of the larvae.

Sheep also may be dipped, which involves drenching the animals in persistent insecticide to poison the larvae before they develop into a problem.

Use of myiasitic maggots in medicine[edit]

Throughout recorded history maggots have been used therapeutically to clean out necrotic wounds, an application known as maggot therapy.

Fly larvae that feed on dead tissue can clean wounds and may reduce bacterial activity and the chance of a secondary infection. They dissolve dead tissue by secreting digestive enzymes onto the wound as well as actively eating the dead tissue with “mouth hooks,” two hard, probing appendages protruding on either side of the "mouth".[17] Maggot therapy – also known as maggot debridement therapy (MDT), larval therapy, larva therapy, or larvae therapy – is the intentional introduction by a health care practitioner of live, disinfected green bottle fly maggots (larvae) into the non-healing skin and soft tissue wound(s) of a human or other animal for the purpose of selectively cleaning out only the necrotic (dead) tissue within a wound in order to promote wound healing.

Maggot therapy has a long history and prehistory. The indigenous people of Australia used maggot therapy, and so do the Hill Peoples of Northern Burma, and possibly the Mayans of Central America.[2] Surgeons in Napoleon’s armies recognized that wounded soldiers with myiasis were more likely to survive than those without the infestation. In the American Civil War, army surgeons treated wounds by allowing blowfly maggots to clean away the decayed tissue.

Dr. William Baer, an orthopedic surgeon at Johns Hopkins during the late 1920s, used maggot therapy to treat a series of patients with osteomyelitis, an infection of bone or bone marrow. The idea was based on an experience in World War I in which two soldiers presented to him with broken femurs after having lain on the ground for seven days without food and water. Dr. Baer could not figure out why neither man had a fever or signs of sepsis. He observed: “On removing the clothing from the wounded part, much was my surprise to see the wound filled with thousands and thousands of maggots, apparently those of the blow fly. The sight was very disgusting and measures were taken hurriedly to wash out these abominable looking creatures.” However, he then saw that the wounds were filled with “beautiful pink granulation tissue” and were healing well.[18]

Maggot therapy was common in the United States during the 1930s. However, during the second half of the twentieth century, after the introduction of antibiotics, maggot therapy was only used as a last resort for very serious wounds.[2] Lately maggots have been making a comeback due to the increased resistance of bacteria to antibiotics.

Although maggot therapy has been used in the US for the past 80 years, it was approved by the FDA as a “medical device” only in 2004 (along with leeches in the same year).[19] Maggots were the first live organism to be marketed in the US according to FDA regulations, and are approved for treating neuropathic (diabetic) foot ulcers, pressure ulcers, venous stasis ulcers, and traumatic and post-surgical wounds that are unresponsive to conventional therapies. Before this, maggots were in fact being used but were unregulated. Richard Sherman, a doctor in Irvine, CA, is the best-known maggot therapy advocate and began treating patients with maggots in 1990.[19] He is now the laboratory director of Monarch Labs, the first commercial producer of medical grade maggots. This lab has provided maggots and maggot therapy supplies since 1935.[20]

Today, there is an ever-increasing demand for medical maggots. In the US, demand for these fly larvae doubled after the FDA ruling. Maggot therapy is now used in more than 300 sites across the country.[17] The American Medical Association and Centers for Medicare and Medicaid Services recently clarified the reimbursement guidelines to the wound care community for medicinal maggots, and this therapy may soon be covered by insurance.[21] The larvae of the green bottle fly (a type of blow-fly) are now used exclusively for this purpose, since they preferentially devour only necrotic tissue, leaving healthy tissue intact. This is an important distinction, as most other major varieties of myiasitic fly larvae attack both live and dead wound tissue indiscriminately, effectively negating their benefit in non-harmful wound debridement. Medicinal maggots are placed on the wound and covered with a sterile dressing of gauze and nylon mesh. Too many larvae placed on the wound could result in healthy tissue being eaten.[4]

See also[edit]

References[edit]

  1. ^ Otranto, Domenico. “The immunology of myiasis: parasite survival and host defense strategies.” Trends in Parasitology 17 (2001): 4.
  2. ^ a b c d e f g h John, David and Petri, William. Markell and Voge’s Medical Parasitology: 9th Edition. Missouri: Saunders Elsevier, 2006. p. 328-334.
  3. ^ "Introduction to myiasis | Natural History Museum". Nhm.ac.uk. Retrieved 2013-11-05. 
  4. ^ a b Sherman, RA, Hall, MJR, and Thomas, S. “Medicinal Maggots: An ancient remedy for some contemporary afflictions.” Annual Review of Entomology 45 (2000): 55-81.
  5. ^ Hill, Dennis S. (1997). The economic importance of insects. Springer. p. 102. ISBN 0412498006. 
  6. ^ a b Janovy, John; Schmidt, Gerald D.; Roberts, Larry S. (1996). Gerald D. Schmidt & Larry S. Roberts' Foundations of parasitology. Dubuque, Iowa: Wm. C. Brown. ISBN 0-697-26071-2. 
  7. ^ Zumpt, Fritz Konrad Ernst; Myiasis in man and animals in the old world. Butterworth 1965
  8. ^ Ockenhouse, Christian, Samlaska, Curt, Benson, Paul, Roberts, Lyman, Eliasson, Arn, Malane, Susan, and Menich, Mark. “Cutaneous myiasis caused by the African tumbu fly.” Archives of Dermatology 126 (1990):199-202.
  9. ^ a b Lagacé-Wiens, Philippe; Dookeran, Ravi; Skinner, Stuart; Leicht, Richard; Colwell, Douglas D.; Galloway, Terry D. (2008). "Human Ophthalmomyiasis Interna Caused by Hypoderma tarandi, Northern Canada". Emerging Infectious Diseases 14 (1): 64–6. doi:10.3201/eid1401.070163. PMC 2600172. PMID 18258079. Retrieved 22 June 2011. 
  10. ^ Wound myiasis in a patient with squamous cell carcinoma. Namazi MR, Fallahzadeh MK. ScientificWorldJournal. 2009 Nov 1;9:1192-3. doi: 10.1100/tsw.2009.138.[1],
  11. ^ "Screwworm flies as agents of wound myiasis". Fao.org. Retrieved 2013-11-05. 
  12. ^ El-Azazy, O.M.E. 1989. Wound myiasis caused by Cochliomyia hominivorax in Libya. Vet. Rec., 124: 103
  13. ^ Not the Usual Suspects: Human Wound Myiasis by Phorids. T. E. Huntington, David W. Voigt, and L. G. Higley. Journal of Medical Entomology Jan 2008 : Vol. 45, Issue 1, pg(s) 157-159 doi: 10.1603/0022-2585(2008)45[157:NTUSHW]2.0.CO;2
  14. ^ Cleveland Clinic (13 August 2010). Current Clinical Medicine: Expert Consult - Online. Elsevier Health Sciences. pp. 1396–. ISBN 978-1-4377-3571-0. Retrieved 22 April 2013. 
  15. ^ a b Adisa, Charles and Mbanaso, Augustus. “Furuncular myiasis of the breast caused by the larvae of the Tumbu fly (Cordylobia anthropophaga).” BMC Surgery 4 (2004): 5.
  16. ^ "Standard Operating Procedures - sheep Mulesing". teacher's notes. New South Wales Department of Primary Industries. March 8, 2004. Retrieved 2007-01-09. 
  17. ^ a b Greer, Kathleen. “Age-old therapy gets new approval.” Advances in Skin & Wound Care. January/February 2005.
  18. ^ Baer, William. “The treatment of chronic osteomyelitis with the maggot (larva of the blow fly).” Journal of Bone and Joint Surgery 13 (1931): 438-475.
  19. ^ a b Rubin, Rita (2004-07-07). "Maggots and leeches: Good medicine". Usatoday.Com. Retrieved 2013-11-05. 
  20. ^ "Home | School of Medicine | University of California, Irvine". Healthaffairs.uci.edu. Retrieved 2013-11-05. 
  21. ^ "Insurance may soon cover maggot therapy - Health - Health care | NBC News". MSNBC. 2008-11-19. Retrieved 2013-11-05. 

External links[edit]