Myocardial perfusion imaging

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Myocardial perfusion imaging
Nl mpi2.jpg
Nuclear medicine myocardial perfusion scan with Thallium-201 for the rest images (bottom rows) and Tc-Sestamibi for the stress images (top rows). The nuclear medicine myocardial perfusion scan plays a pivotal role in the noninvasive evaluation of coronary artery disease. The study not only identifies some patients who have coronary artery disease, it can also provide overall prognostic information or overall risk of adverse cardiac events for the patient, provided that the patient does not suffer from Three-Vessel disease, the most serious result of coronary artery disease.
MeSH D055414
OPS-301 code: 3-704, 3-721

Myocardial perfusion scan (also referred to as MPI) is a nuclear medicine procedure that illustrates the function of the heart muscle (myocardium).[1]

It evaluates many heart conditions from coronary artery disease (CAD) to hypertrophic cardiomyopathy and myocardial wall motion abnormalities. The function of the myocardium is also evaluated by calculating the left ventricular ejection fraction (LVEF) of the heart. This scan is done in conjunction with a cardiac stress test.

Planar techniques, such as conventional scintigraphy, are rarely used. Rather, SPECT is more common in the US. With multihead SPECT systems, imaging can often be completed in less than 10 minutes. With SPECT, interior and posterior abnormalities and small areas of infarction can be identified, as well as the occluded blood vessels and the mass of infarcted and viable myocardium.[2]

Major indications for a myocardial perfusion test[edit]

  • Diagnosis of CAD and various cardiac abnormalities.
  • Identifying location, criticality of existing coronary stenosis and degree of coronary artery disease (CAD) in patients with a history of CAD.
  • Prognostication (risk stratification) and evaluation of patients that are at risk of having a myocardial or coronary incident. (ex: myocardial infarction, myocardial ischemia, coronary aneurysm, wall motion abnormalities)
  • Assessment of viable myocardium in particular coronary artery territory following heart attacks to justify revascularization
  • Post intervention revascularization (coronary artery bypass graft, angioplasty) evaluation of heart.

Risks vs. benefits[edit]

Critics have written that myocardial perfusion imaging is associated with an increased risk of cancer due to high radiation doses that are not justified by randomized, controlled studies demonstrating benefit[citation needed]. However, radiation doses received during CT angiography and conventional coronary angiography are higher than those received during myocardial perfusion imaging done with 99m-Technetium labelled agents[citation needed]. The psychological block associated with radioactive materials may be responsible for these fears.

In a study of patient exposure to low-dose ionizing radiation, myocardial perfusion imaging had the highest average effective dose (15.6 millisieverts) and the highest percentage (22.1%) of all effective doses to the entire patient population from all major radiological procedures, including computer tomographic studies. Older patients, 60 to 64 years old, had the highest doses, with 5.27% getting a high dose (>20 to 50 mSv/year) and 0.57% getting a very high dose (>50 mSv/year) from all sources.[3]

Experimental and epidemiologic evidence has linked exposure to low-dose ionizing radiation with up to 2% of solid cancers and leukemia. Workers are monitored and limited to 100mSv every 5 years, but medical patients are not typically monitored.

Interestingly, the concern over radiation hazard has undermined the risk associated with the allergic potential of radiocontrast (dyes) used in CT angiography and coronary angiography. In myocardial perfusion imaging, radioisotopes are used in nanomole quantities, practically devoid of any risk of allergy with normal saline being used as the vehicle and no known adverse reaction to the chemical molecules (sestamibi or tetrofosmine)[citation needed].

From 1993-2001, myocardial perfusion scans increased >6%/y with "no justification," according to a commentary by Lauer. Mycardial perfusion imaging scans are "powerful predictors of future clinical events," and in theory may identify patients for whom aggressive therapies should improve outcome. But this is "only a hypothesis, not a proof," wrote Lauer. There are no randomized, controlled trials to demonstrate any benefits, and there is a small but cumulative danger from radiation.[4]

However, radioisotope MPI is considered to be the most comprehensive test[citation needed], providing information about criticality of coronary stenosis, area suffering from ischemia, severity of ischemia, total mass of viable myocardium, and the pump function of the heart, along with objective parameters such as end systolic volume, end diastolic volume, stroke volume and ejection fraction. The negative predictive value of the test is as high as 98%[citation needed], offering excellent prognostic value.

New radionuclides such as rubidium-82 reduce the radiation dose to the patient by a factor of 10 compared to technetium-99m. In the future, therefore, a complete myocardial perfusion exam may be achievable while maintaining a patient dose under 3 mSv.[5][6] Stress-only protocols may also prove to be effective at reducing costs and patient exposure.[7]


  1. ^ Myocardial Perfusion Imaging at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ^ Merck manuals > Radionuclide Imaging Last full review/revision May 2009 by Michael J. Shea, MD. Content last modified May 2009
  3. ^ Exposure to low-dose ionizing radiation from medical imaging procedures, Reza Fazel et al. N Engl J Med, 27 Aug 2009, 361(9):849.
  4. ^ Perspective: Elements of danger -- the case of medical imaging, Michael S. Lauer, N Engl J Med, 27 Aug 2009, 361(9):841.
  5. ^ A revised effective dose estimate for the PET perfusion tracer Rb-82, deKemp et al, J NUCL MED MEETING ABSTRACTS, 2008. 49(MeetingAbstracts_1): p. 183P-b-.
  6. ^ Radiopharmaceuticals for nuclear cardiology: radiation dosimetry, uncertainties, and risk., Stabin et al, J Nucl Med, 2008. 49(9): p. 1555-63.
  7. ^ Stress-only Nuclear Myocardial Perfusion Imaging, Heston TF, Internet Med J, accessed 17-Feb-2012.