Myogenic contraction

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Myogenic contraction refers to a contraction initiated by the myocyte cell itself instead of an outside occurrence or stimulus such as nerve innervation. Most often observed (although not necessarily restricted to) in smaller resistance arteries, this 'basal' tone may be useful in the regulation of organ blood flow and peripheral resistance, as it positions a vessel in a preconstricted state that allows other factors to induce additional constriction or dilation to increase or decrease blood flow.

Mechanisms[edit]

Unstable Membrane Potentials[edit]

Many cells have resting membrane potentials that are unstable. This instability is usually due to ion channels in the cell membrane that spontaneously open and close (e.g. If channels in cardiac pacemaker cells). When the membrane potential reaches depolarization threshold an action potential (AP) is fired, excitation-contraction coupling initiates and the myocyte contracts.

Slow wave potentials[edit]

Slow wave potential are unstable resting membrane potentials that continuously cycle through depolarization- and repolarization phases. However, not every cycle reaches depolarization threshold and thus an action potential (AP) will not always fire. Owing to temporal summation (depolarization potentials spaced closely together in time so that they summate), however, cell membrane depolarization will periodically reach depolarization threshold and an action potential will fire, triggering contraction of the myocyte.

Pacemaker potentials[edit]

Pacemaker potentials are unstable cell membrane potentials that reach depolarization threshold with every depolarization/repolarization cycle. This results in AP's being fired according to a set rhythm. Cardiac pacemaker cells, a type of cardiac myocyte in the SA node of heart, are an example of cells with a pacemaker potential.

Stretch[edit]

This mechanism involves the opening of mechanically-gated Ca2+ channels when some myocytes are stretched. The resulting influx of Ca2+ ions lead to the initiation of excitation-contraction coupling and thus contraction of the myocyte.

See also[edit]

Membrane potential
Action potential
Excitation-contraction coupling
Myogenic mechanism (Myogenic reflex)