Myxoid liposarcoma

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Myxoid liposarcoma
Classification and external resources
Myxoid liposarcoma (01).jpg
Histopathologic image of myxoid liposarcoma arising in the deep soft tissue of the thigh. H & E stain.
ICD-O: 8852/3
OMIM 613488
MeSH D018208

A myxoid liposarcoma is a malignant adipose tissue neoplasm.

It is associated with a fusion between DDIT3 or "CHOP" (at 12q13.1-q13.2) and FUS or "TLS" (at 16p11.2) or EWS (at 22q12.2).[1]

The specific translocation of FUS-DDIT3 is t(12;16)(q13;p11).[2]

References[edit]

  1. ^ Forni C, Minuzzo M, Virdis E, et al. (February 2009). "Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors". Mol. Cancer Ther. 8 (2): 449–57. doi:10.1158/1535-7163.MCT-08-0848. PMID 19190116. 
  2. ^ Göransson M, Andersson MK, Forni C, et al. (January 2009). "The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ". Oncogene 28 (2): 270–8. doi:10.1038/onc.2008.378. PMID 18850010.