N,alpha-Diethylphenylethylamine (N,α-DEPEA) is a close chemical analog of methamphetamine. It was originally patented, by Knoll Pharma as one of several analogs for pharmaceutical applications. In animals models these analogs showed properties of cognitive enhancement and increased pain tolerance. Nevertheless, this class of compounds was never developed into a medicine. N,α-DEPEA has not been studied in humans, but experts such as Pieter Cohen, an assistant professor of medicine at Harvard Medical School, expect it to be less potent than methamphetamine but greater than ephedrine.
In January 2013, the Korean authorities reported seizing a large quantity of the pure material, predicting it would soon be found on the market.
In August 2013, the first paper was published on N,α-DEPEA being found in the pre-workout supplement Craze.
In October 2013 it was announced that N,alpha-diethylphenylethylamine was found in biologically significant amounts in the pre-workout supplements Craze (marketed by Driven Sports, Inc.) and Detonate (marketed by Gaspari Nutrition).