|CAS number||, S|
|PubChem||, R, S|
|Beilstein Reference||1726198 S|
|Jmol-3D images||Image 1
|Molar mass||175.14 g mol−1|
|Appearance||Colourless, transparent crystals|
137-140 °C, 410-413 K, 279-284 °F
141-144 °C, 414-417 K, 286-291 °F
|Related alkanoic acids|
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
N-Acetylaspartic acid, or N-acetylaspartate (NAA), is a derivative of aspartic acid with a formula of C6H9NO5 and a molecular weight of 175.139.
NAA is the second-most-concentrated molecule in the brain after the amino acid glutamate. It is detected in the adult brains only in neurons  synthesized in the mitochondria of neurons from the amino acid aspartic acid and acetyl-coenzyme A. The various functions served by NAA are still under investigation, but the primary proposed functions include its being:
- A neuronal osmolyte that is involved in fluid balance in the brain
- A source of acetate for lipid and myelin synthesis in oligodendrocytes, the glial cells that myelinate neuronal axons
- A precursor for the synthesis of the important neuronal dipeptide N-Acetylaspartylglutamate
- A contributor to energy production from the amino acid glutamate in neuronal mitochondria.
In the brain, NAA is thought to be present predominantly in neuronal cell bodies, where it acts as a neuronal marker. NAA gives off the largest signal in magnetic resonance spectroscopy of the human brain, and the levels measured there are decreased in numerous neuropathological conditions ranging from brain injury to stroke to Alzheimer's disease. This fact makes NAA a reliable diagnostic molecule for doctors treating patients with brain damage or disease.
||This article includes a list of references, but its sources remain unclear because it has insufficient inline citations. (May 2009)|
- N-Acetylaspartate: A Unique Neuronal Molecule in the Central Nervous System, eds., J.R.Moffett, S.B.Tieman, D.R.Weinberger, J.T.Coyle, and M.A.Namboodiri, pp. 7–26. New York, NY: Springer Science + Business Media, 2006.
- Biochemical Support for the "Threshold" Theory of Creativity: A Magnetic Resonance Spectroscopy Study, Rex E. Jung et al., April 22, 2009, 29(16):5319-5325; doi:10.1523/JNEUROSCI.0588-09.2009
- "N-acetylaspartate - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 26 March 2005. Identification. Retrieved 8 January 2012.
- (Simmons, Frondoza et al. 1991 PMID 1754068; Moffett, Namboodiri et al. 1991 )
- Patel, T. B. and J. B. Clark (1979). "Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport." Biochem J 184(3): 539-46. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1754068
- Chatham JC, Blackband SJ. (2001). "Nuclear magnetic resonance spectroscopy and imaging in animal research.". ILAR J 42 (3): 189–208. PMID 11406719.
- Kozlovskiy, S, Vartanov, A, Pyasik, M, Polikanova, I. (2012). "Working memory and N-acetylaspartate level in hippocampus, parietal cortex and subventricular zone". International Journal of Psychology, vol. 47. P. 584. doi:10.1080/00207594.2012.709117