N-Methyl-L-glutamic acid

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N-Methyl-L-glutamic acid
N-methyl-L-glutamic acid.svg
CAS number 6753-62-4
ChemSpider 388497
Jmol-3D images Image 1
Molecular formula C6H11NO4
Molar mass 161.16 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

N-Methyl-L-glutamic acid (methylglutamate) is a chemical derivative of glutamic acid in which a methyl group has been added to the amino group. It is an intermediate in methane metabolism. Biosynthetically, it is produced from methylamine and glutamic acid by the enzyme methylamine—glutamate N-methyltransferase.[1] It can also be demethylated by methylglutamate dehydrogenase to regenerate glutamic acid.[2]


  1. ^ Shaw, WV; Tsai, L; Stadtman, ER (1966). "The enzymatic synthesis of N-methylglutamic acid". The Journal of Biological Chemistry 241 (4): 935–45. PMID 5905132. 
  2. ^ Hersh, LB; Stark, MJ; Worthen, S; Fiero, MK (1972). "N-methylglutamate dehydrogenase: Kinetic studies on the solubilized enzyme". Archives of biochemistry and biophysics 150 (1): 219–26. doi:10.1016/0003-9861(72)90029-X. PMID 5028076.