N-Acetylglutamic acid

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N-Acetylglutamic acid
Skeletal formula of N-acetylglutamic acid
CAS number 5817-08-3 N, 19146-55-5 R YesY, 1188-37-0 S YesY
PubChem 185, 1560015 R, 70914 S
ChemSpider 180 YesY, 1272049 R YesY, 64077 S YesY
EC number 227-388-6
DrugBank DB04075
KEGG C00624 N
MeSH N-acetylglutamate
RTECS number LZ9725000 S
1727473 S
3DMet B00147
Jmol-3D images Image 1
Image 2
Molecular formula C7H11NO5
Molar mass 189.17 g mol−1
Appearance White crystals
Density 1 g mL−1
Melting point 191 to 194 °C (376 to 381 °F; 464 to 467 K)
Solubility in water 36 g L−1
LD50 >7 g kg−1 (oral, rat)
Related compounds
Related alkanoic acids
Related compounds
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

N-Acetylglutamic acid (abbreviated NAcGlu) is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetylglutamate synthase. Arginine is the activator for this reaction.

The reverse reaction, hydrolysis of the acetyl group, is catalyzed by a specific hydrolase.

NAcGlu activates carbamoyl phosphate synthetase in the urea cycle.

See also[edit]


  1. ^ "N-Acetyl-DL-glutamic acid - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Retrieved 25 June 2012. 

External links[edit]