N-myc-interactor

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N-myc (and STAT) interactor
Identifiers
Symbol NMI
External IDs OMIM603525 MGI1928368 HomoloGene3441 GeneCards: NMI Gene
RNA expression pattern
PBB GE NMI 203964 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9111 64685
Ensembl ENSG00000123609 ENSMUSG00000026946
UniProt Q13287 O35309
RefSeq (mRNA) NM_004688 NM_001141948
RefSeq (protein) NP_004679 NP_001135420
Location (UCSC) Chr 2:
152.13 – 152.15 Mb
Chr 2:
51.95 – 51.97 Mb
PubMed search [1] [2]

N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.[1][2][3]

Function[edit]

NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.[3]

Interactions[edit]

NMI (gene) has been shown to interact with BRCA1,[4] IFI35,[5] Myc,[4] and STAT5A,[2] and TUBA3C.[6]

References[edit]

  1. ^ Bao J, Zervos AS (Aug 1996). "Isolation and characterization of Nmi, a novel partner of Myc proteins". Oncogene 12 (10): 2171–6. PMID 8668343. 
  2. ^ a b Zhu M, John S, Berg M, Leonard WJ (Mar 1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell 96 (1): 121–30. doi:10.1016/S0092-8674(00)80965-4. PMID 9989503. 
  3. ^ a b "Entrez Gene: NMI N-myc (and STAT) interactor". 
  4. ^ a b Li H, Lee TH, Avraham H (June 2002). "A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer". J. Biol. Chem. 277 (23): 20965–73. doi:10.1074/jbc.M112231200. PMID 11916966. 
  5. ^ Chen J, Shpall RL, Meyerdierks A, Hagemeier M, Böttger EC, Naumovski L (November 2000). "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35". J. Biol. Chem. 275 (46): 36278–84. doi:10.1074/jbc.M006975200. PMID 10950963. 
  6. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]