NAD+ kinase

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NAD+ kinase
NADK.png
Ribbon diagram of NAD+ kinase in complex with substrates.[1]
Identifiers
EC number 2.7.1.23
CAS number 9032-66-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
NAD kinase
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NADK ; dJ283E3.1
External IDs OMIM611616 MGI2183149 HomoloGene49724 ChEMBL: 6177 GeneCards: NADK Gene
EC number 2.7.1.23
RNA expression pattern
PBB GE NADK 208917 x at tn.png
PBB GE NADK 208918 s at tn.png
PBB GE NADK 208919 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 65220 192185
Ensembl ENSG00000008130 ENSMUSG00000029063
UniProt O95544 P58058
RefSeq (mRNA) NM_001198993 NM_001159637
RefSeq (protein) NP_001185922 NP_001153109
Location (UCSC) Chr 1:
1.68 – 1.71 Mb
Chr 4:
155.56 – 155.59 Mb
PubMed search [1] [2]

NAD+ kinase (EC 2.7.1.23, NADK) is an enzyme that converts nicotinamide adenine dinucleotide (NAD+) into NADP+, through phosphorylating the NAD+ coenzyme.[2] NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis.[3] The structure of the NADK from the archaean Archaeoglobus fulgidus has been determined.[1]

In humans, NAD+ kinase is encoded by the NADK gene.[4]

Reaction[edit]

ATP + NAD+ \rightleftharpoons ADP + NADP+

See also[edit]

References[edit]

  1. ^ a b PDB 1SUW; Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH (November 2005). "Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP". J. Mol. Biol. 354 (2): 289–303. doi:10.1016/j.jmb.2005.09.026. PMID 16242716. 
  2. ^ Magni G, Orsomando G, Raffaelli N (2006). "Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis". Mini reviews in medicinal chemistry 6 (7): 739–46. doi:10.2174/138955706777698688. PMID 16842123. 
  3. ^ Pollak N, Dölle C, Ziegler M (2007). "The power to reduce: pyridine nucleotides – small molecules with a multitude of functions". Biochem. J. 402 (2): 205–18. doi:10.1042/BJ20061638. PMC 1798440. PMID 17295611. 
  4. ^ Lerner F, Niere M, Ludwig A, Ziegler M (October 2001). "Structural and functional characterization of human NAD kinase". Biochem. Biophys. Res. Commun. 288 (1): 69–74. doi:10.1006/bbrc.2001.5735. PMID 11594753. 

Further reading[edit]

External links[edit]