NAGA (gene)

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N-acetylgalactosaminidase, alpha-
Protein NAGA PDB 3H53.png
Rendering based on PDB 3H53.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NAGA ; D22S674; GALB
External IDs OMIM104170 MGI1261422 HomoloGene221 ChEMBL: 3132 GeneCards: NAGA Gene
EC number 3.2.1.49
RNA expression pattern
PBB GE NAGA 202943 s at tn.png
PBB GE NAGA 202944 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4668 17939
Ensembl ENSG00000198951 ENSMUSG00000022453
UniProt P17050 Q9QWR8
RefSeq (mRNA) NM_000262 NM_008669
RefSeq (protein) NP_000253 NP_032695
Location (UCSC) Chr 22:
42.45 – 42.47 Mb
Chr 15:
82.33 – 82.34 Mb
PubMed search [1] [2]

Alpha-N-acetylgalactosaminidase is an enzyme that in humans is encoded by the NAGA gene.[1]

NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease).[1]

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