NASP (gene)

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Nuclear autoantigenic sperm protein (histone-binding)
Symbols NASP ; FLB7527; PRO1999
External IDs OMIM603185 MGI1355328 HomoloGene133894 GeneCards: NASP Gene
RNA expression pattern
PBB GE NASP 201969 at tn.png
PBB GE NASP 201970 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4678 50927
Ensembl ENSG00000132780 ENSMUSG00000028693
UniProt P49321 Q99MD9
RefSeq (mRNA) NM_001195193 NM_001081475
RefSeq (protein) NP_001182122 NP_001074944
Location (UCSC) Chr 1:
46.05 – 46.08 Mb
Chr 4:
116.6 – 116.63 Mb
PubMed search [1] [2]

Nuclear autoantigenic sperm protein is a protein that in humans is encoded by the NASP gene.[1][2] Multiple isoforms are encoded by transcript variants of this gene.


This gene encodes a histone H1 binding protein that is involved in transporting histones into the nucleus of dividing cells.[3] The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.[2]


  1. ^ O'Rand MG, Richardson RT, Zimmerman LJ, Widgren EE (Dec 1992). "Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein". Dev Biol 154 (1): 37–44. doi:10.1016/0012-1606(92)90045-I. PMID 1426632. 
  2. ^ a b "Entrez Gene: NASP nuclear autoantigenic sperm protein (histone-binding)". 
  3. ^ Alekseev OM, Widgren EE, Richardson RT, O'Rand MG (January 2005). "Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei". J. Biol. Chem. 280 (4): 2904–11. doi:10.1074/jbc.M410397200. PMID 15533935. 

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