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Neighbor of BRCA1 gene 1
Protein NBR1 PDB 1wj6.png
PDB rendering based on 1wj6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NBR1 ; 1A1-3B; IAI3B; M17S2
External IDs OMIM166945 MGI108498 HomoloGene7438 GeneCards: NBR1 Gene
Species Human Mouse
Entrez 4077 17966
Ensembl ENSG00000188554 ENSMUSG00000017119
UniProt Q14596 P97432
RefSeq (mRNA) NM_001291571 NM_001252220
RefSeq (protein) NP_001278500 NP_001239149
Location (UCSC) Chr 17:
41.32 – 41.36 Mb
Chr 11:
101.55 – 101.58 Mb
PubMed search [1] [2]

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.[1][2]

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[2]


NBR1 has been shown to interact with FEZ1.[3]


  1. ^ Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304. 
  2. ^ a b "Entrez Gene: NBR1 neighbor of BRCA1 gene 1". 
  3. ^ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. (Germany) 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312. 

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