Condensin complex subunit 2 also known as chromosome-associated protein H (CAP-H) or non-SMC condensin I complex subunit H (NCAPH) is a protein that in humans is encoded by the NCAPHgene. CAP-H is a subunit of condensin I, a large protein complex involved in chromosome condensation
CAP-H is a member of the barr protein family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphasechromatin into condensed chromosomes. CAP-H is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and three significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice and an increased susceptibility to bacterial infection was observed in male animals.
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Heale JT; Ball AR; Schmiesing JA et al. (2006). "Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair". Mol. Cell21 (6): 837–48. doi:10.1016/j.molcel.2006.01.036. PMID16543152.Cite uses deprecated parameter |author-separator= (help)
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