Neutrophil cytosolic factor 2

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Neutrophil cytosolic factor 2
Protein NCF2 PDB 1e96.png
PDB rendering based on 1e96.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NCF2 ; NCF-2; NOXA2; P67-PHOX; P67PHOX
External IDs OMIM608515 MGI97284 HomoloGene374 GeneCards: NCF2 Gene
RNA expression pattern
PBB GE NCF2 209949 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4688 17970
Ensembl ENSG00000116701 ENSMUSG00000026480
UniProt P19878 O70145
RefSeq (mRNA) NM_000433 NM_010877
RefSeq (protein) NP_000424 NP_035007
Location (UCSC) Chr 1:
183.52 – 183.56 Mb
Chr 1:
152.81 – 152.84 Mb
PubMed search [1] [2]

Neutrophil cytosol factor 2 is a protein that in humans is encoded by the NCF2 gene.

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease.[1]

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