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Nuclear receptor coactivator 5
Protein NCOA5 PDB 1v95.png
PDB rendering based on 1v95.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NCOA5 ; CIA; bA465L10.6
External IDs MGI2385165 HomoloGene32496 GeneCards: NCOA5 Gene
Species Human Mouse
Entrez 57727 228869
Ensembl ENSG00000124160 ENSMUSG00000039804
UniProt Q9HCD5 Q91W39
RefSeq (mRNA) NM_020967 NM_144892
RefSeq (protein) NP_066018 NP_659141
Location (UCSC) Chr 20:
44.69 – 44.72 Mb
Chr 2:
165 – 165.03 Mb
PubMed search [1] [2]

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.[1][2]


This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor Rev-ErbA beta. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.[1]


  1. ^ a b "Entrez Gene: NCOA5 nuclear receptor coactivator 5". 
  2. ^ Sauvé F, McBroom LD, Gallant J, Moraitis AN, Labrie F, Giguère V (January 2001). "CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant". Molecular and Cellular Biology 21 (1): 343–53. doi:10.1128/MCB.21.1.343-353.2001. PMC 88807. PMID 11113208. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.