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Nuclear receptor coactivator 6
Symbols NCOA6 ; AIB3; ASC2; NRC; PRIP; RAP250; TRBP
External IDs OMIM605299 MGI1929915 HomoloGene40920 GeneCards: NCOA6 Gene
RNA expression pattern
PBB GE NCOA6 208979 at tn.png
More reference expression data
Species Human Mouse
Entrez 23054 56406
Ensembl ENSG00000198646 ENSMUSG00000038369
UniProt Q14686 A2AQM9
RefSeq (mRNA) NM_001242539 NM_001242558
RefSeq (protein) NP_001229468 NP_001229487
Location (UCSC) Chr 20:
33.28 – 33.41 Mb
Chr 2:
155.39 – 155.47 Mb
PubMed search [1] [2]

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.[1][2][3]


The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.[3]


NCOA6 has been shown to interact with:

See also[edit]


  1. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (November 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849. 
  2. ^ Estey A, Kemp M, Allison S, Lamb C (January 1994). "Evaluation of a patient information booklet". J Nurs Staff Dev 9 (6): 278–82. PMID 8263591. 
  3. ^ a b "Entrez Gene: NCOA6 nuclear receptor coactivator 6". 
  4. ^ a b c d e f g Goo Y, Sohn Y, Kim D, Kim S, Kang M, Jung D et al. (January 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. 23 (1): 140–9. doi:10.1128/mcb.23.1.140-149.2003. PMC 140670. PMID 12482968. 
  5. ^ Hong S, Choi H, Park M, Kim Y, Choi Y, Kim H et al. (April 2004). "Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid". J. Biol. Chem. 279 (17): 16996–7003. doi:10.1074/jbc.M311752200. PMID 14734562. 
  6. ^ a b Goo Y, Na S, Zhang H, Xu J, Hong S, Cheong J et al. (February 2004). "Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation". J. Biol. Chem. 279 (8): 7131–5. doi:10.1074/jbc.M312563200. PMID 14645241. 
  7. ^ a b c d e f g Lee S, Anzick S, Choi J, Bubendorf L, Guan X, Jung Y et al. (November 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404. 
  8. ^ a b c d e f g Lee S, Jung S, Kim Y, Na S, Lee Y, Lee J (February 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. doi:10.1210/me.15.2.241. PMID 11158331. 
  9. ^ a b c d e f Ko L, Cardona G, Chin W (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961. 
  10. ^ Kong H, Yu H, Hong S, Park M, Choi Y, An W et al. (November 2003). "Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation". Mol. Cancer Res. 1 (13): 948–58. PMID 14638867. 
  11. ^ a b c d Ko L, Cardona G, Iwasaki T, Bramlett K, Burris T, Chin W (January 2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. 16 (1): 128–40. doi:10.1210/mend.16.1.0755. PMID 11773444. 
  12. ^ a b Kong H, Park M, Hong S, Yu H, Lee Y, Choi Y et al. (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865. 
  13. ^ Hong S, Kim S, Heo M, Choi Y, Park M, Yoo M et al. (February 2004). "Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock". FEBS Lett. 559 (1-3): 165–70. doi:10.1016/S0014-5793(04)00028-6. PMID 14960326. 
  14. ^ a b Ko L, Chin W (March 2003). "Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase". J. Biol. Chem. 278 (13): 11471–9. doi:10.1074/jbc.M209723200. PMID 12519782. 
  15. ^ a b Lee S, Na S, Jung S, Choi J, Jhun B, Cheong J et al. (June 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. 14 (6): 915–25. doi:10.1210/mend.14.6.0471. PMID 10847592. 
  16. ^ Misra P, Qi C, Yu S, Shah S, Cao W, Rao M et al. (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212. 
  17. ^ Zhu Y, Qi C, Cao W, Yeldandi A, Rao M, Reddy J (August 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10380–5. doi:10.1073/pnas.181347498. PMC 56969. PMID 11517327. 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.