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NDC80 kinetochore complex component
Protein NDC80 PDB 2igp.png
PDB rendering based on 2igp.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NDC80 ; HEC; HEC1; HsHec1; KNTC2; TID3; hsNDC80
External IDs OMIM607272 MGI1914302 HomoloGene38141 ChEMBL: 5660 GeneCards: NDC80 Gene
RNA expression pattern
PBB GE NDC80 204162 at tn.png
More reference expression data
Species Human Mouse
Entrez 10403 67052
Ensembl ENSG00000080986 ENSMUSG00000024056
UniProt O14777 Q9D0F1
RefSeq (mRNA) NM_006101 NM_023294
RefSeq (protein) NP_006092 NP_075783
Location (UCSC) Chr 18:
2.57 – 2.62 Mb
Chr 17:
71.5 – 71.53 Mb
PubMed search [1] [2]

Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.[1][2][3]

HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[supplied by OMIM][3]


NDC80 has been shown to interact with MIS12,[4][5] NEK2[6][7] and PSMC2.[7]


  1. ^ Chen Y, Riley DJ, Chen PL, Lee WH (Oct 1997). "HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis". Mol Cell Biol 17 (10): 6049–56. PMC 232454. PMID 9315664. 
  2. ^ Martin-Lluesma S, Stucke VM, Nigg EA (Sep 2002). "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2". Science 297 (5590): 2267–70. doi:10.1126/science.1075596. PMID 12351790. 
  3. ^ a b "Entrez Gene: NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae)". 
  4. ^ Cheeseman, Iain M; Niessen Sherry; Anderson Scott; Hyndman Francie; Yates John R; Oegema Karen; Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. (United States) 18 (18): 2255–68. doi:10.1101/gad.1234104. ISSN 0890-9369. PMC 517519. PMID 15371340. 
  5. ^ Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. (England) 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821. 
  6. ^ Chen, Yumay; Riley Daniel J; Zheng Lei; Chen Phang-Lang; Lee Wen-Hwa (Dec 2002). "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation". J. Biol. Chem. (United States) 277 (51): 49408–16. doi:10.1074/jbc.M207069200. ISSN 0021-9258. PMID 12386167. 
  7. ^ a b Chen, Y; Sharp Z D; Lee W H (Sep 1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". J. Biol. Chem. (UNITED STATES) 272 (38): 24081–7. doi:10.1074/jbc.272.38.24081. ISSN 0021-9258. PMID 9295362. 

Further reading[edit]