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NudE neurodevelopment protein 1-like 1
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM607538 MGI1932915 HomoloGene32567 GeneCards: NDEL1 Gene
RNA expression pattern
PBB GE NDEL1 208093 s at tn.png
More reference expression data
Species Human Mouse
Entrez 81565 83431
Ensembl ENSG00000166579 ENSMUSG00000018736
UniProt Q9GZM8 Q9ERR1
RefSeq (mRNA) NM_001025579 NM_023668
RefSeq (protein) NP_001020750 NP_076157
Location (UCSC) Chr 17:
8.32 – 8.39 Mb
Chr 11:
68.82 – 68.87 Mb
PubMed search [1] [2]

Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.[1][2][3]

This gene encodes a thiol-activated oligopeptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]


NDEL1 has been shown to interact with Cyclin-dependent kinase 5,[1] YWHAE,[4] PAFAH1B1[1][4] and DISC1.[5][6]


  1. ^ a b c Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH (Feb 2001). "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein". Neuron 28 (3): 697–711. doi:10.1016/S0896-6273(00)00147-1. PMID 11163260. 
  2. ^ Sasaki S, Shionoya A, Ishida M, Gambello MJ, Yingling J, Wynshaw-Boris A, Hirotsune S (Feb 2001). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system". Neuron 28 (3): 681–96. doi:10.1016/S0896-6273(00)00146-X. PMID 11163259. 
  3. ^ a b "Entrez Gene: NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1". 
  4. ^ a b Toyo-oka, Kazuhito; Shionoya Aki, Gambello Michael J, Cardoso Carlos, Leventer Richard, Ward Heather L, Ayala Ramses, Tsai Li-Huei, Dobyns William, Ledbetter David, Hirotsune Shinji, Wynshaw-Boris Anthony (Jul 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nat. Genet. (United States) 34 (3): 274–85. doi:10.1038/ng1169. ISSN 1061-4036. PMID 12796778. 
  5. ^ Morris, Jill A; Kandpal Geeta; Ma Lei; Austin Christopher P (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. (England) 12 (13): 1591–608. doi:10.1093/hmg/ddg162. ISSN 0964-6906. PMID 12812986. 
  6. ^ Ozeki, Yuji; Tomoda Toshifumi, Kleiderlein John, Kamiya Atsushi, Bord Lyuda, Fujii Kumiko, Okawa Masako, Yamada Naoto, Hatten Mary E, Snyder Solomon H, Ross Christopher A, Sawa Akira (Jan 2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (1): 289–94. doi:10.1073/pnas.0136913100. ISSN 0027-8424. PMC 140954. PMID 12506198. 

Further reading[edit]