NDN (gene)

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Necdin, melanoma antigen (MAGE) family member
Identifiers
Symbols NDN ; HsT16328; PWCR
External IDs OMIM602117 MGI97290 HomoloGene20559 GeneCards: NDN Gene
RNA expression pattern
PBB GE NDN 209550 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4692 17984
Ensembl ENSG00000182636 ENSMUSG00000033585
UniProt Q99608 P25233
RefSeq (mRNA) NM_002487 NM_010882
RefSeq (protein) NP_002478 NP_035012
Location (UCSC) Chr 15:
23.93 – 23.93 Mb
Chr 7:
62.35 – 62.35 Mb
PubMed search [1] [2]

Necdin is a protein that in humans is encoded by the NDN gene.[1][2]

This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.[2]

Functions[edit]

Necdin is used to stimulate growth regulation,and DNA-dependent transcription regulation.[3]

Interactions[edit]

NDN (gene) has been shown to interact with NUCB2,[4] E2F1,[5][6] IL1A,[7] Low affinity nerve growth factor receptor,[6][8][9] P53[10] and HNRNPU.[11]

References[edit]

  1. ^ MacDonald HR, Wevrick R (January 1998). "The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse". Hum Mol Genet 6 (11): 1873–8. doi:10.1093/hmg/6.11.1873. PMID 9302265. 
  2. ^ a b "Entrez Gene: NDN necdin homolog (mouse)". 
  3. ^ Uniprot
  4. ^ Taniguchi, N; Taniura H; Niinobe M; Takayama C; Tominaga-Yoshino K; Ogura A; Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. (UNITED STATES) 275 (41): 31674–81. doi:10.1074/jbc.M005103200. ISSN 0021-9258. PMID 10915798. 
  5. ^ Taniura, H; Taniguchi N; Hara M; Yoshikawa K (January 1998). "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1". J. Biol. Chem. (UNITED STATES) 273 (2): 720–8. doi:10.1074/jbc.273.2.720. ISSN 0021-9258. PMID 9422723. 
  6. ^ a b Kuwako, Ken-ichiro; Taniura Hideo; Yoshikawa Kazuaki (January 2004). "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. (United States) 279 (3): 1703–12. doi:10.1074/jbc.M308454200. ISSN 0021-9258. PMID 14593116. 
  7. ^ Hu, Bo; Wang Shuhui; Zhang Yingze; Feghali Carol A; Dingman Jeffrey R; Wright Timothy M (August 2003). "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (17): 10008–13. doi:10.1073/pnas.1737765100. ISSN 0027-8424. PMC 187743. PMID 12913118. 
  8. ^ Bronfman, Francisca C; Tcherpakov Marianna; Jovin Thomas M; Fainzilber Mike (April 2003). "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. (United States) 23 (8): 3209–20. PMID 12716928. 
  9. ^ Tcherpakov, Marianna; Bronfman Francisca C; Conticello Silvestro G; Vaskovsky Anna; Levy Zehava; Niinobe Michio; Yoshikawa Kazuaki; Arenas Ernest; Fainzilber Mike (December 2002). "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. (United States) 277 (51): 49101–4. doi:10.1074/jbc.C200533200. ISSN 0021-9258. PMID 12414813. 
  10. ^ Taniura, H; Matsumoto K; Yoshikawa K (June 1999). "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. (UNITED STATES) 274 (23): 16242–8. doi:10.1074/jbc.274.23.16242. ISSN 0021-9258. PMID 10347180. 
  11. ^ Taniura, Hideo; Yoshikawa Kazuaki (2002). "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. (United States) 84 (3): 545–55. doi:10.1002/jcb.10047. ISSN 0730-2312. PMID 11813259. 

Further reading[edit]