This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutations in this gene have been reported to be causative the autosomal-recessive version of Charcot-Marie-Tooth disease known as CMT4D. It has been reported that NDRG1 localizes to the endosomes and is a Rab4a effector involved in vesicular recycling.
^van Belzen N, Dinjens WN, Diesveld MP, Groen NA, van der Made AC, Nozawa Y, Vlietstra R, Trapman J, Bosman FT (Sep 1997). "A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms". Lab Invest77 (1): 85–92. PMID9251681.
^Kokame K, Kato H, Miyata T (Jan 1997). "Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes". J Biol Chem271 (47): 29659–65. doi:10.1074/jbc.271.47.29659. PMID8939898.
^Zhang J, Chen S, Zhang W, Zhang J, Liu X, Shi H, Che H, Wang W, Li F, Yao L (Jun 2008). "Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region". Gene417 (1-2): 5–12. doi:10.1016/j.gene.2008.03.002. PMID18455888.
Kalaydjieva L, Hallmayer J, Chandler D, et al. (1996). "Gene mapping in Gypsies identifies a novel demyelinating neuropathy on chromosome 8q24.". Nat. Genet.14 (2): 214–7. doi:10.1038/ng1096-214. PMID8841199.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Zhou D, Salnikow K, Costa M (1998). "Cap43, a novel gene specifically induced by Ni2+ compounds.". Cancer Res.58 (10): 2182–9. PMID9605764.
Kurdistani SK, Arizti P, Reimer CL, et al. (1998). "Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage.". Cancer Res.58 (19): 4439–44. PMID9766676.
Piquemal D, Joulia D, Balaguer P, et al. (1999). "Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells.". Biochim. Biophys. Acta1450 (3): 364–73. doi:10.1016/S0167-4889(99)00056-7. PMID10395947.
Guan RJ, Ford HL, Fu Y, et al. (2000). "Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer.". Cancer Res.60 (3): 749–55. PMID10676663.
Park H, Adams MA, Lachat P, et al. (2000). "Hypoxia induces the expression of a 43-kDa protein (PROXY-1) in normal and malignant cells.". Biochem. Biophys. Res. Commun.276 (1): 321–8. doi:10.1006/bbrc.2000.3475. PMID11006124.
Rutherford MN, Bayly GR, Matthews BP, et al. (2001). "The leukemogenic transcription factor E2a-Pbx1 induces expression of the putative N-myc and p53 target gene NDRG1 in Ba/F3 cells.". Leukemia15 (3): 362–70. doi:10.1038/sj.leu.2402059. PMID11237058.
Zhou RH, Kokame K, Tsukamoto Y, et al. (2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart.". Genomics73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID11352569.
Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.". Mol. Cell. Biochem.229 (1-2): 35–44. doi:10.1023/A:1017934810825. PMID11936845.
Cangul H, Salnikow K, Yee H, et al. (2002). "Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis.". Cell Biol. Toxicol.18 (2): 87–96. doi:10.1023/A:1015376032736. PMID12046693.
Lachat P, Shaw P, Gebhard S, et al. (2003). "Expression of NDRG1, a differentiation-related gene, in human tissues.". Histochem. Cell Biol.118 (5): 399–408. doi:10.1007/s00418-002-0460-9. PMID12432451.
Segawa T, Nau ME, Xu LL, et al. (2003). "Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells.". Oncogene21 (57): 8749–58. doi:10.1038/sj.onc.1205992. PMID12483528.
Symes, AJ, Eilertsen, M and Millar, M et al. (2013). "Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue". PLoS ONE8 (12): e84295. doi:10.1371/journal.pone.0084295.