NDRG1

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N-myc downstream regulated 1
Identifiers
Symbols NDRG1 ; CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5
External IDs OMIM605262 MGI1341799 HomoloGene55953 GeneCards: NDRG1 Gene
RNA expression pattern
PBB GE NDRG1 200632 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10397 17988
Ensembl ENSG00000104419 ENSMUSG00000005125
UniProt Q92597 Q62433
RefSeq (mRNA) NM_001135242 NM_008681
RefSeq (protein) NP_001128714 NP_032707
Location (UCSC) Chr 8:
134.25 – 134.31 Mb
Chr 15:
66.93 – 66.97 Mb
PubMed search [1] [2]

Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.[1][2][3][4]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation[citation needed]. Mutations in this gene have been reported to be causative the autosomal-recessive version of Charcot-Marie-Tooth disease known as CMT4D.[4] It has been reported that NDRG1 localizes to the endosomes and is a Rab4a effector involved in vesicular recycling.[5]

References[edit]

  1. ^ van Belzen N, Dinjens WN, Diesveld MP, Groen NA, van der Made AC, Nozawa Y, Vlietstra R, Trapman J, Bosman FT (Sep 1997). "A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms". Lab Invest 77 (1): 85–92. PMID 9251681. 
  2. ^ Kokame K, Kato H, Miyata T (Jan 1997). "Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes". J Biol Chem 271 (47): 29659–65. doi:10.1074/jbc.271.47.29659. PMID 8939898. 
  3. ^ Zhang J, Chen S, Zhang W, Zhang J, Liu X, Shi H, Che H, Wang W, Li F, Yao L (Jun 2008). "Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region". Gene 417 (1-2): 5–12. doi:10.1016/j.gene.2008.03.002. PMID 18455888. 
  4. ^ a b "Entrez Gene: NDRG1 N-myc downstream regulated gene 1". 
  5. ^ Kachhap SK, Faith D, Qian DZ, et al. (2007). "The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin". In Heisenberg, Carl-Philipp. PLoS ONE 2 (9): e844. doi:10.1371/journal.pone.0000844. PMC 1952073. PMID 17786215. 

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