NDUFA8

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NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
Identifiers
Symbols NDUFA8 ; CI-19KD; CI-PGIV; PGIV
External IDs OMIM603359 MGI1915625 HomoloGene40932 ChEMBL: 3294 GeneCards: NDUFA8 Gene
EC number 1.6.5.3, 1.6.99.3
RNA expression pattern
PBB GE NDUFA8 218160 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4702 68375
Ensembl ENSG00000119421 ENSMUSG00000026895
UniProt P51970 Q9DCJ5
RefSeq (mRNA) NM_014222 NM_026703
RefSeq (protein) NP_055037 NP_080979
Location (UCSC) Chr 9:
124.89 – 124.92 Mb
Chr 2:
36.04 – 36.05 Mb
PubMed search [1] [2]

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 is an enzyme that in humans is encoded by the NDUFA8 gene.[1][2]

The protein encoded by this gene belongs to the complex I 19 kDA subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transferring electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.[2]

References[edit]

  1. ^ Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet 82 (1-2): 115–9. doi:10.1159/000015082. PMID 9763677. 
  2. ^ a b "Entrez Gene: NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa". 

Further reading[edit]