NDUFB2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
Identifiers
Symbols NDUFB2 ; AGGG; CI-AGGG
External IDs OMIM603838 MGI1915448 HomoloGene3341 GeneCards: NDUFB2 Gene
EC number 1.6.5.3, 1.6.99.3
RNA expression pattern
PBB GE NDUFB2 218200 s at tn.png
PBB GE NDUFB2 218201 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4708 68198
Ensembl ENSG00000090266 ENSMUSG00000002416
UniProt O95178 Q9CPU2
RefSeq (mRNA) NM_004546 NM_026612
RefSeq (protein) NP_004537 NP_080888
Location (UCSC) Chr 7:
140.39 – 140.42 Mb
Chr 6:
39.59 – 39.6 Mb
PubMed search [1] [2]

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial is an enzyme that in humans is encoded by the NDUFB2 gene.[1][2][3]

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transferring electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I.[3]

References[edit]

  1. ^ Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet 82 (1–2): 115–9. doi:10.1159/000015082. PMID 9763677. 
  2. ^ Loeffen JL, Triepels RH, van den Heuvel LP, Schuelke M, Buskens CA, Smeets RJ, Trijbels JM, Smeitink JA (Jan 1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem Biophys Res Commun 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551. 
  3. ^ a b "Entrez Gene: NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa". 

Further reading[edit]