NDUFB6

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NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
Identifiers
Symbols NDUFB6 ; B17; CI
External IDs OMIM603322 MGI2684983 HomoloGene1864 ChEMBL: 2192 GeneCards: NDUFB6 Gene
EC number 1.6.5.3, 1.6.99.3
RNA expression pattern
PBB GE NDUFB6 203613 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4712 230075
Ensembl ENSG00000165264 ENSMUSG00000071014
UniProt O95139 Q3UIU2
RefSeq (mRNA) NM_001199987 NM_001033305
RefSeq (protein) NP_001186916 NP_001028477
Location (UCSC) Chr 9:
32.55 – 32.57 Mb
Chr 4:
40.27 – 40.28 Mb
PubMed search [1] [2]

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 also known as complex I-B17 is a protein that in humans is encoded by the NDUFB6 gene.[1][2][3]

Function[edit]

The protein encoded by this gene is an accessory subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I) that is not directly involved in catalysis. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein complex has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.[3]

References[edit]

  1. ^ Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet 82 (1-2): 115–9. doi:10.1159/000015082. PMID 9763677. 
  2. ^ Smeitink J, Loeffen J, Smeets R, Triepels R, Ruitenbeek W, Trijbels F, van den Heuvel L (Oct 1998). "Molecular characterization and mutational analysis of the human B17 subunit of the mitochondrial respiratory chain complex I". Hum Genet 103 (2): 245–50. doi:10.1007/s004390050813. PMID 9760212. 
  3. ^ a b "Entrez Gene: NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa". 

Further reading[edit]