From Wikipedia, the free encyclopedia
Jump to: navigation, search
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
Symbols NDUFB7 ; B18; CI-B18
External IDs OMIM603842 MGI1914166 HomoloGene3059 ChEMBL: 2357 GeneCards: NDUFB7 Gene
EC number,
RNA expression pattern
PBB GE NDUFB7 202839 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4713 66916
Ensembl ENSG00000099795 ENSMUSG00000033938
UniProt P17568 Q9CR61
RefSeq (mRNA) NM_004146 NM_025843
RefSeq (protein) NP_004137 NP_080119
Location (UCSC) Chr 19:
14.68 – 14.68 Mb
Chr 8:
83.57 – 83.57 Mb
PubMed search [1] [2]

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 is an enzyme that in humans is encoded by the NDUFB7 gene.[1][2][3]

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.[3]


  1. ^ Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet 82 (1–2): 115–9. doi:10.1159/000015082. PMID 9763677. 
  2. ^ Triepels R, Smeitink J, Loeffen J, Smeets R, Trijbels F, van den Heuvel L (Jun 2000). "Characterization of the human complex I NDUFB7 and 17.2-kDa cDNAs and mutational analysis of 19 genes of the HP fraction in complex I-deficient-patients". Hum Genet 106 (4): 385–91. doi:10.1007/s004390000278. PMID 10830904. 
  3. ^ a b "Entrez Gene: NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa". 

Further reading[edit]